Functional movements of the GABA type A receptor

Varnai Csilla; Irwin B. W. J.; Payne M. C.; Csanyi Gabor; Chau P-L

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Functional movements of the GABA type A receptor

机译：GABA型受体的功能运动

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We have performed a parallel tempering crankshaft motion Monte Carlo simulation on a model of the GABA type A receptor with the aim of exploring a wide variety of local conformational space. We develop a novel method to analyse the protein movements in terms of a correlation tensor and use this to explore the gating process, that is, how agonist binding could cause ion channel opening. We find that simulated binding impulses to varying clusters of GABA binding site residues produce channel opening, and that equivalent impulses to single GABA sites produce partial opening.

机译：我们在GABA型的模型上进行了平行的回火曲轴运动Monte Carlo模拟，其目的是探索各种局部构象空间。我们开发了一种新的方法，以分析相关张量的蛋白质运动，并用它来探索浇注过程，即激动剂结合如何导致离子通道开口。我们发现模拟结合脉冲到改变GABA结合位点残留物产生通道开口的簇，并且对单个GABA位点的等效脉冲产生部分开口。

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来源
《Physical chemistry chemical physics: PCCP》 |2020年第28期|共9页
作者
Varnai Csilla; Irwin B. W. J.; Payne M. C.; Csanyi Gabor; Chau P-L;
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作者单位

Univ Birmingham Ctr Computat Biol Birmingham B15 2TT W Midlands England;

Univ Cambridge Dept Phys Cavendish Lab Cambridge CB3 0HE England;

Univ Cambridge Dept Phys Cavendish Lab Cambridge CB3 0HE England;

Univ Cambridge Dept Engn Cambridge CB2 1PZ England;

Inst Pasteur CNRS URA 3528 CB3I CNRS USR 3756 Bioinformat Struct F-75724 Paris France;

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正文语种 eng
中图分类物理学;化学;
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1. Functional movements of the GABA type A receptor [J] . Varnai Csilla, Irwin B. W. J., Payne M. C., Physical chemistry chemical physics: PCCP . 2020,第28期

机译：GABA型受体的功能运动
2. Hypotensive Response to Angiotensin II Type 2 Receptor Stimulation in the Rostral Ventrolateral Medulla Requires Functional GABA-A Receptors [J] . Légat Laura, Brouwers Sofie, Smolders Ilse J., Frontiers in Neuropharmacology . 2019,第4期

机译：对血管紧张素II型2受体刺激在罗斯特尔腹膜外髓质中的低脉冲反应需要功能性GABA-A受体
3. Hypotensive Response to Angiotensin II Type 2 Receptor Stimulation in the Rostral Ventrolateral Medulla Requires Functional GABA-A Receptors [J] . Légat, Laura Frontiers in Neuroscience . 2017,第2009期

机译：延髓前侧延髓对血管紧张素II 2型受体刺激的低血压反应需要功能性GABA-A受体
4. Application of bioinformatics algorithms to define the most important protein features contribute to GABA receptors diversity GABA receptors' diversity, bioinformatic applications [C] . Ebrahimi Mansour, Ebrahimie Esmaeil 2nd International Conference on Chemical, Biological and Environmental Engineering . 2010

机译：应用生物信息学算法定义最重要的蛋白质特征有助于GABA受体多样性GABA受体的多样性，生物信息学应用
5. Functional interactions of alpha4beta2*-type nicotinic acetylcholine receptors with GABAB autoreceptors and calcineurin . [D] . McClure-Begley, Tristan David. 2010

机译：alpha4beta2 *型烟碱乙酰胆碱受体与GABAB自身受体和钙调神经磷酸酶的功能相互作用。
6. Hypotensive Response to Angiotensin II Type 2 Receptor Stimulation in the Rostral Ventrolateral Medulla Requires Functional GABA-A Receptors [O] . Laura Légat, Sofie Brouwers, Ilse J. Smolders, 2017

机译：延髓前侧延髓对血管紧张素II 2型受体刺激的低血压反应需要功能性GABA-A受体
7. Blockade of GABA, type A, receptors in the rat pontine reticular formation induces rapid eye movement sleep that is dependent upon the cholinergic system [O] . G.A. Marks, O.W. Sachs, C.G. Birabil 2008

机译：封锁GABA，A型，大鼠猪网状形成的受体诱导依赖于胆碱能系统的快速眼睛运动睡眠

Functional movements of the GABA type A receptor

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