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首页> 外文期刊>Current opinion in anaesthesiology >Lung injury after thoracic surgery and one-lung ventilation.
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Lung injury after thoracic surgery and one-lung ventilation.

机译：胸外科手术和单肺通气后肺损伤。

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摘要

PURPOSE OF REVIEW: An update is provided for anaesthetists, on recent work investigating the incidence and cause of lung injury following thoracic surgery. Pulmonary damage is also discussed in relation to the management of one-lung ventilation. RECENT FINDINGS: The extent of recent original literature on lung injury, following thoracic surgery, is limited for the review period (2004-2005). Increasing evidence that pulmonary oxidative stress and an increase in proinflammatory cytokines are significant contributors to lung injury following thoracic surgery, however, exists. This is particularly the case in patients with lung or oesophageal carcinoma. Animal experiments confirm the above and also indicate that anaesthetic agents may offer some protection against the ischaemia-reperfusion injury sustained as a result of one-lung ventilation. SUMMARY: Pulmonary damage in the form of acute lung injury and adult respiratory distress syndrome is a major cause of morbidity and mortality after thoracic surgery. An understanding of the pathogenesis of lung damage, following thoracic surgery, may enable anaesthetists to modify this process and decrease the incidence and severity of the problem.
机译：审查目的：为麻醉师提供有关胸腔手术后肺损伤发生率和原因的最新研究的最新资料。还讨论了与单肺通气管理有关的肺损伤。最近的发现：在回顾期间（2004-2005年），有关胸外科手术后肺损伤的最新原始文献范围有限。越来越多的证据表明，肺氧化应激和促炎细胞因子的增加是造成胸外科手术后肺损伤的重要因素。在患有肺癌或食道癌的患者中尤其如此。动物实验证实了上述内容，并且还表明，麻醉药可能会对单肺通气导致的局部缺血-再灌注损伤提供一定的保护。摘要：急性肺损伤和成人呼吸窘迫综合征形式的肺损伤是胸外科手术后发病和死亡的主要原因。对胸外科手术后肺损伤的发病机理的了解，可使麻醉师改变这一过程并降低问题的发生率和严重性。

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