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首页> 外文期刊>Phytochemistry >Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla
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Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla

机译：稀有濒危植物的植物化学和生物学研究。 第XIV部分。 来自濒危植物Picea Brachytyla的树枝和针的结构不同的三萜类化合物

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A phytochemical investigation on the MeOH extract of the twigs and needles of the endangered plant Picea brachytyla led to the isolation and characterization of thirty-eight structurally diverse terpenoids. Seven of these molecules are previously undescribed, including three abietane-type (brachytylins A-C) and one labdane-type (brachytylin D) diterpenoids, an unseparated C-24 epimeric mixture of cycloartane-type triterpenoids (brachytylins E/F, ratio: 1:1), and a rare rearranged 12(1 -> 6)-abeo-megastigmane glycoside (brachytylins G). Their structures and absolute configurations were determined by extensive spectroscopic (e.g., detailed 2D NMR and ECD) methods and/or X-ray diffraction analyses. All the isolates were evaluated for their inhibitory activities against the adenosine triphosphate (ATP)-citrate lyase (ACL) and the Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). Among them, abiesadine J showed inhibitory effect against ACL, displaying an IC50 value of 17 mu M. 3S,23R-Dihydroxycycloart-24-en-26-oic acid exhibited inhibitory effect on SHP2, with an IC50 value of 19 mu M. Meanwhile, 3R*,23S*-dihydroxycycloart-24-en-26-oic acid was found to have inhibitory effects against both ACL and SHP2, with IC50 values of 16 and 12 mu M, respectively.
机译：濒危植物Picea Brachytyla的树枝和针的MeOH提取物的植物化学研究导致了三十八种结构多种萜类化合物的分离和表征。这些分子中的七种是未被描述的，包括三种上一型（Brachylins AC）和一种Labdane型（Brachytylin D）二萜类萜类，其环丙烷型三萜类蛋白（Brachylins E / F，比例：1：1：1） 1），并且罕见重排12（1 - > 6）-Abe-Megastigmane糖苷（Brachytylins G）。它们的结构和绝对构态由广泛的光谱（例如，详细的2D NMR和ECD）方法和/或X射线衍射分析来确定。评估所有分离株对腺苷三磷酸（ATP）柠檬酸裂解酶（ACL）和含有蛋白质酪氨酸磷酸酶-2（SHP2）的SRC同源-2结构域的抑制活性。其中，Abiesadine J表现出对ACL的抑制作用，显示IC50值为17 mu M. 3S，23r-二羟基环藻藻酸-24-ZH-26-OIC酸在SHP2上表现出抑制作用，IC50值为19μm。同时发现3R *，23s * -dihydroxycycloArt-24-en-26-陶酸对ACL和SHP2具有抑制作用，分别具有16和12μm的IC50值。

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