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首页> 外文期刊>Current oncology reports. >In reply: Response to Sammartino et al.
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In reply: Response to Sammartino et al.

机译：回复：对Sammartino等人的回应。

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A wealth of evidence has established that cholesterol-lowering statin drugs, widely used for the prevention of cardiovascular disease, do increase the risk of new-onset diabetes, possibly by impairing pancreatic beta cell function and decreasing peripheral insulin sensitivity. Groups at particular risk include the elderly, women, and Asians. The diabetogenic effect of statins appear directly related to statin dose and the degree of attained cholesterol lowering. Statins can cause hyperinsulinemia even in the absence of hyperglycemia and the potential mitogenic effects and implications of prolonged hyperinsulinemia are discussed. Suggestions are made as to how physicians might avert the hyperinsulinemic and diabetogenic effects of statin therapy in clinical practice, and modulate the detrimental effects of these drugs on exercise performance. Finally, long-term studies are needed to determine if the deleterious hyperinsulinemic and diabetogenic effects of statin therapy undermine the beneficial cardiovascular disease risk outcomes in various segments of the population.
机译：大量证据表明，降低胆固醇的他汀类药物（广泛用于预防心血管疾病）确实会增加胰腺β细胞功能并降低外周胰岛素敏感性，从而确实增加了新发糖尿病的风险。高危人群包括老年人，妇女和亚洲人。他汀类药物的致糖尿病作用与他汀类药物的剂量和胆固醇降低的程度直接相关。他汀类药物即使在没有高血糖的情况下也可以引起高胰岛素血症，并讨论了潜在的促有丝分裂作用和长期高胰岛素血症的影响。提出了有关医生如何在临床实践中避免他汀类药物治疗的高胰岛素和糖尿病的影响，以及如何调节这些药物对运动表现的有害影响的建议。最后，需要进行长期研究，以确定他汀类药物治疗的有害性高胰岛素和致糖尿病作用是否会破坏人群中各方面有益的心血管疾病风险。

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