...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in allergy and clinical immunology >Are antihistamines useful in managing asthma?
【24h】

Are antihistamines useful in managing asthma?

机译：抗组胺药对治疗哮喘有用吗？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There continues to be a great deal of interest in the anti-asthmatic role of antihistamines. Antihistamines have recently been shown to have anti-inflammatory properties that are more extensive than simply the blocking of histamine receptors. For example, new evidence suggests that the suppression of cell adhesion molecule expression occurs with these drugs. The anti-inflammatory and anti-asthmatic effects of antihistamines have been evaluated in patients with both allergic asthma and rhinitis, given the established association between allergic inflammation of the upper and lower airways, with evidence to suggest that antihistamines have clinically relevant anti-asthmatic properties. As well as conferring benefits in asthma symptom control and the measurement of lung function, studies assessing the effect of histamine receptor antagonists on bronchial hyperresponsiveness suggest that there is bronchoprotection during both methacholine and mannitol challenges. Recently, there has also been considerable interest in the effect of combining an antihistamine with a leukotriene receptor antagonist. This combination has an anti-asthmatic effect that is greater than that of either drug given alone and may be comparable to inhaled corticosteroid therapy.
机译：抗组胺药的抗哮喘作用仍然引起人们极大的兴趣。抗组胺剂近来已显示出具有比简单地阻断组胺受体更广泛的抗炎特性。例如，新证据表明这些药物会抑制细胞粘附分子的表达。考虑到上呼吸道和下呼吸道的过敏性炎症之间已建立的联系，已经评估了过敏性哮喘和鼻炎患者中抗组胺药的抗炎和抗哮喘作用，并有证据表明抗组胺药具有临床相关的抗哮喘特性。评估组胺受体拮抗剂对支气管高反应性的影响以及对哮喘症状控制和肺功能测量的益处，以及研究表明，在乙酰甲胆碱和甘露醇攻击期间均具有支气管保护作用。近来，在将抗组胺药与白三烯受体拮抗剂结合的效果上也引起了相当大的兴趣。这种组合具有的抗哮喘作用大于单独使用的任何一种药物，并且可以与吸入糖皮质激素治疗相媲美。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号