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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Erythrocyte binding proteins of malaria parasites: potential targets for intervention
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Erythrocyte binding proteins of malaria parasites: potential targets for intervention

机译：疟原虫的红细胞结合蛋白：潜在的干预目标

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摘要

Erythrocyte invasion by Plasmodium merozoites is mediated by molecular interactions between parasite proteins and host receptors. We describe molecular, genetic, biochemical and structural studies to understand the functional roles played by a family of erythrocyte binding proteins (EBPs) from malaria parasites in the process of red cell invasion. These together with field-based immuno-epidemiology studies have been used to build the rationale for the use of EBPs as malaria vaccine candidates. Parasite proteins such as EBPs that mediate interactions with host receptors are commonly localized in apical organelles. Successful invasion requires timely secretion of these parasite proteins during invasion. We describe here efforts to understand signalling mechanisms that trigger timely secretion of EBPs and other parasite ligands from apical organelles during invasion. Such signalling pathways may provide novel drug targets for inhibition of invasion and parasite growth.
机译：疟原虫裂殖子入侵红细胞是由寄生虫蛋白和宿主受体之间的分子相互作用介导的。我们描述分子，遗传，生化和结构研究，以了解由疟疾寄生虫在红细胞入侵过程中的红细胞结合蛋白（EBPs）家族发挥的功能作用。这些与基于现场的免疫流行病学研究一起已被用于建立将EBP用作疟疾疫苗候选药物的理由。介导与宿主受体相互作用的寄生虫蛋白（例如EBP）通常位于顶端细胞器中。成功的入侵需要在入侵过程中及时分泌这些寄生虫蛋白。我们在这里描述努力了解信号机制，以触发入侵过程中从根尖细胞器及时分泌EBPs和其他寄生虫配体。此类信号传导途径可为抑制侵袭和寄生虫生长提供新的药物靶标。

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