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首页> 外文期刊>Current opinion in anaesthesiology >Role of glutamine supplementation in critically ill patients.
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Role of glutamine supplementation in critically ill patients.

机译：补充谷氨酰胺在危重病人中的作用。

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PURPOSE OF REVIEW: To update the documentation concerning the clinical use of glutamine supplementation in critically ill patients. Outcome, patient safety and future plans are examined. RECENT FINDINGS: In terms of outcome studies, the last 2 years have added little to our knowledge. A number of multi-centre studies are under way, however, which can be expected to give better evidence for the use of glutamine in the near future. In terms of patient safety, several new studies have demonstrated metabolic tolerance, vascular tolerance, losses in conjunction with continuous renal replacement therapy and the relation to intracerebral glutamate in head trauma. Glutamine losses in continuous renal replacement therapy are not negligible, and are actually a further argument for exogenous glutamine supplementation. Losses of supplemented glutamine into the dialysate are not a problem. SUMMARY: The use of intravenous glutamine supplementation in critically ill patients on total parenteral nutrition is currentlythe standard of care. The use of exogenous glutamine supplementation in critically ill patients on enteral nutrition is still not supported by sufficient evidence. The use of plasma glutamine concentration as an indicator for glutamine deficiency and a possible indicator for supplementation is suggested.
机译：审查目的：更新有关危重患者谷氨酰胺补充临床使用的文献。研究结果，患者安全和未来计划。最近的发现：在结果研究方面，最近两年对我们的知识了解甚微。然而，许多多中心研究正在进行中，可以预料在不久的将来将为使用谷氨酰胺提供更好的证据。在患者安全方面，多项新研究已证明了代谢耐受性，血管耐受性，连续肾脏替代治疗伴随的损失以及与颅脑谷氨酸在颅脑创伤中的关系。连续性肾脏替代治疗中的谷氨酰胺损失不可忽略，实际上是外源性谷氨酰胺补充的另一个论点。补充的谷氨酰胺损失到透析液中不是问题。简介：目前，在危重患者中采用肠胃外营养补充静脉内补充谷氨酰胺是目前的护理标准。尚无足够证据支持在危重患者中接受肠内营养补充外源谷氨酰胺。建议使用血浆谷氨酰胺浓度作为谷氨酰胺缺乏症的指标和可能的补充指标。

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