首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Decaying wood as a natural habitat oil melanin-forming (Mel(+)) variant of Cryptococcus laurentii
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Decaying wood as a natural habitat oil melanin-forming (Mel(+)) variant of Cryptococcus laurentii

机译:腐烂木材作为劳氏隐球菌的天然栖息地油黑色素形成(Mel(+))变体

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The association of a melanin-forming (Mel(+)) variant of Cryptococcus laurentii with decaying sal wood, Shorea robusta, is reported here. The variant was cultured from 8 of the 14 samples of the wood detritus collected over a period of two and a half years. The average population density of the fungus was found to be 1x10(4) colony forming units (CFU)/g of the wood substrate. The variant was not detected in any of the 702 samples of miscellaneous plant materials, such as bark of Eucalyptus camaldulensis, E. tereticornis, Eugenia jumbolina, Syzygium cumini, Ficus religiosa, etc., slime flux of various trees and Sphagnum moss. Likewise, it was not detected in any of the 181 samples of bat guano and 137 of sail. The repeated isolation of the Mel(+) variant in considerable numbers from the S. robusta wood detritus indicates that decaying wood may serve as a natural habitat for this fungus. This observation is of considerable epidemiologic importance since phenoloxidase (melanin-forming) activity is a virulence factor in Cryptococcus neoformans, a well known pulmonary anal meningeal yeast pathogen of humans and animals. Also, it was noteworthy that the Mel(+) variant incited macroscopic lesions on the liver and spleen of intraperitoneally infected cortisone-treated (immunosuppressed) white mice, indicating that the fungus is a potential opportunistic pathogen. [References: 21]
机译:此处报道了劳氏隐球菌的黑色素形成(Mel(+))变体与腐朽的婆罗洲木(Shorenarobusta)的关联。在两年半的时间里,从14种木屑碎屑样本中的8种培养变体。发现真菌的平均种群密度为1x10(4)菌落形成单位(CFU)/ g木材底物。在702种其他植物材料样品中均未检测到该变体,例如桉树桉树皮,大肠埃希氏菌,非洲菊,树形蒲桃,无花果树等的树皮,各种树木和泥炭藓的泥浆通量。同样,在181只蝙蝠鸟粪和137帆的样本中均未检测到。从健壮链霉菌木屑中大量分离出Mel(+)变种,表明腐烂的木材可能是这种真菌的自然栖息地。由于酚氧化酶(黑色素形成)活性是新隐隐球菌(一种人类和动物的肺肛门脑膜酵母病原体)中的毒力因子,因此该观察具有重要的流行病学重要性。另外,值得注意的是,Mel(+)变异体诱发了腹膜内感染可的松治疗(免疫抑制)的白色小鼠肝脏和脾脏的宏观损害,表明该真菌是潜在的机会病原体。 [参考:21]

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