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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >SISTER CHROMATID COHESION DURING MEIOSIS - DIFFERENTIAL MECHANISMS FOR ARMS AND CENTROMERE COHERENCE [Review]
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SISTER CHROMATID COHESION DURING MEIOSIS - DIFFERENTIAL MECHANISMS FOR ARMS AND CENTROMERE COHERENCE [Review]

机译:减数分裂过程中的严重染色体粘附-臂和中心相干性的差异机制[综述]

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摘要

Sister chromatid cohesion is a fundamental aspect of chromosome behaviour which ensures faithful disjunction of chromosomes. The differential release of centromeric- and arm-cohesion during meiosis suggests that the molecular basis of cohesion in the two domains might be different. A number of meiotic mutations differentially affect cohesion in the two domains, Recent identification of two proteins, ORD and mei-S332, shows that they are involved in maintaining cohesion in two spatially different locations, While mei-S332 acts to structurally hold the sister centromeres together until second meiotic anaphase, ORD is likely to time the release of cohesion along the arms during first meiotic division. [References: 47]
机译:姐妹染色单体内聚是染色体行为的基本方面,可确保忠实分离染色体。减数分裂过程中着丝粒和臂凝聚力的差异释放表明,两个域内凝聚力的分子基础可能不同。许多减数分裂突变差异影响两个域的凝聚力,最近鉴定的两种蛋白质,ORD和mei-S332,表明它们参与维持两个空间不同位置的凝聚力,而mei-S332则在结构上保持姐妹着丝粒直到第二次减数分裂后期,ORD可能会在第一次减数分裂分裂期间确定沿臂的内聚力释放时间。 [参考:47]

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