Cell cycle control and cancer

Garrett MA

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Cell cycle control and cancer

机译：细胞周期控制与癌症

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Cancer is a multifaceted disease, but a common feature of most tumours is that. they harbour one or more genetic mutations that allow them to proliferate outside their normal growth restraints. Proliferation is normally restrained through control of the cell division cycle, which in turn, is regulated by the Cdk family of serine/threonine kinases and their regulatory partners the cyclins. Here, the roles of the Cdk/cyclin complexes in cell cycle control are described followed by a review of the genetic lesions in these and associated proteins which may contribute to tumour progression.

机译：癌症是多方面的疾病，但是大多数肿瘤的共同特征是癌症。它们具有一种或多种遗传突变，可以使其在正常生长限制之外繁殖。通常通过控制细胞分裂周期来抑制增殖，而细胞分裂周期又受丝氨酸/苏氨酸激酶的Cdk家族及其细胞周期蛋白调控伴侣的调控。在此，描述了Cdk /细胞周期蛋白复合物在细胞周期控制中的作用，随后综述了这些蛋白和相关蛋白的遗传损伤，这些遗传损伤可能有助于肿瘤的进展。

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《Current Science: A Fortnightly Journal of Research》 |2001年第5期|共8页
作者
Garrett MA;
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正文语种 eng
中图分类自然科学现状及发展;
关键词
Polo-like kinases; Dna-damage; Dependent kinases; S-phase; Cdk; inhibitors; In-vivo; Phosphorylation; Checkpoint; Protein; Complex;

机译：Polo样激酶;Dna损伤;依赖性激酶;S期;Cdk;抑制剂;体内;磷酸化;检查点;蛋白质;复合物;

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1. 2-氧化戊二酸依赖性加氧酶在10种癌症中的双重预后作用:对细胞周期调节和细胞黏附维持的影响 [J] . Wai Hoong Chang, Donall Forde, Alvina G.Lai 癌症（英文版） . 2020,第001期
2. British Association for Cancer Research/ 'Association of Cancer Physicians/British Society for Cell Biology/Royal Society of Medicine (Oncology Section) Joint Winter Meeting on `Cell cycle control and cellular proliferation' (Incorporating the Gordon Hamilton-Fairley Memorial Lecture and the Alexander Haddow Memorial Lecture) [J] . British Journal of Cancer . 1993,第2期

机译：英国癌症研究协会/“癌症医师协会/英国细胞生物学协会/英国皇家医学会（肿瘤科）联合冬季会议，讨论'细胞周期控制和细胞增殖'（将戈登·汉密尔顿-费尔利纪念演讲和亚历山大一并纳入）哈多纪念讲堂）
3. Cell cycle controlling of cancer stem cells in primary and metastatic colon carcinoma [J] . Kurt F. Ozdal, Kendirci R., Turkoglu C., The FEBS journal . 2016,第Suppla1期

机译：原发性和转移性结肠癌癌干细胞的细胞周期控制
4. Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells [J] . Rudra Kashyap, Bart Roucourt, Frederique Lembo, Frontiers in Pharmacology . 2015,第4期

机译：Syntenin控制癌细胞中的迁移，生长，增殖和细胞周期进程
5. Curcuma zanthorrhiza Extracts Induce G2/M Cell Cycle Arrest and Apoptosis in 4T1 and MCF-7 Human Breast Cancer Cells [C] . Sari Haryanti, Galuh Ratnawati, Nuning Rahmawati International Symposium on Health Research;National Congress of The Indonesian Public Health Association . 2020

机译：Curcuma Zanthorrhiza提取物在4T1和MCF-7人乳腺癌细胞中诱导G2 / M细胞循环骤停和细胞凋亡
6. Discerning the role of LMO4 as a global modulator of G2/M cell cycle progression and centrosome cycle in breast cancer cells. [D] . Montanez-Wiscovich, Marjorie E. 2010

机译：认识到LMO4作为乳腺癌细胞中G2 / M细胞周期进程和中心体周期的整体调节剂的作用。
7. The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells [O] . Soudeh Ghafouri-Fard, Hamed Shoorei, Farhad Tondro Anamag, 2020

机译：非编码RNA在控制细胞周期相关蛋白质中的作用癌细胞
8. British Association for Cancer Research/ 'Association of Cancer Physicians/British Society for Cell Biology/Royal Society of Medicine (Oncology Section) Joint Winter Meeting on `Cell cycle control and cellular proliferation' (Incorporating the Gordon Hamilton-Fairley Memorial Lecture and the Alexander Haddow Memorial Lecture) [O] . 1993

机译：英国癌症研究协会/“癌症医师协会/英国细胞生物学协会/英国皇家医学会（肿瘤科）联合召开关于细胞周期控制和细胞增殖的冬季会议”（将戈登·汉密尔顿-费尔利纪念演讲和亚历山大一并纳入）哈多纪念讲堂）
9. Interactions Between Cell Cycle Control Proteins and the Androgen Receptor in Prostate Cancer [R] . Weinstein, I. B., Lim, J. T. 2005

机译：细胞周期调控蛋白与前列腺癌雄激素受体之间的相互作用

Cell cycle control and cancer

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