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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Haemoglobin D in a mongoloid non-tribal family: A report from northeast India
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Haemoglobin D in a mongoloid non-tribal family: A report from northeast India

机译：蒙古非部落家庭中的血红蛋白D：来自印度东北部的报告

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摘要

Haemoglobin E (HbE) is the most frequently encountered haemoglobin variant among the autochthonous Mongoloid inhabitants of northeastern India. In Assam, besides HbE among the Mongoloid group, sickle cell haemoglobin (HbS) is predominant among the tea-plantation workers. We have documented haemoglobin D (HbD) in an Ahom family belonging to a Mongoloid non-tribal group, in double heterozygous (HbDE) as well as in HbD-heterozygous (HbAD) state from Assam. In India gene frequency for HbD (beta~(121Glu -> Gln)) is relatively low, with a tendency to cluster towards the north-western part of the country. Prevalence of HbD in India has been documented with variable gene frequency from Punjab, Gujarat, Jammu & Kashmir, Uttar Pradesh, Maharashtra, Karnataka, Orissa, West Bengal and Goa, either in the homozygous or heterozygous state. So far, this abnormality has not been reported from the northeastern region of India. Our search in MEDLER, MEDLINE standard and other relevant published literature failed to reveal any report of HbD from this region of the country.
机译：血红蛋白E（HbE）是印度东北部土生蒙古人种中最常遇到的血红蛋白变异体。在阿萨姆邦，除蒙古族人群中的HbE外，镰刀细胞血红蛋白（HbS）在茶叶种植工人中也占主导地位。我们已经从阿萨姆邦以双杂合子（HbDE）以及HbD-杂合子（HbAD）状态记录了属于蒙古非部落族的Ahom家族的Ahom家族中的血红蛋白D（HbD）。在印度，HbD（β〜（121Glu-> Gln））的基因频率相对较低，倾向于向该国西北部聚集。在印度，纯合或杂合状态的旁遮普邦，古吉拉特邦，查mu和克什米尔邦，北方邦，马哈拉施特拉邦，卡纳塔克邦，奥里萨邦，西孟加拉邦和果阿以不同的基因频率记录了HbD的流行。到目前为止，尚未从印度东北地区报告这种异常情况。我们在MEDLER，MEDLINE标准和其他相关发表的文献中进行的搜索未能显示该国该地区的HbD报道。

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