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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Differential scanning calorimetric studies on the interaction of N-acylethanolamines with cholesterol
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Differential scanning calorimetric studies on the interaction of N-acylethanolamines with cholesterol

机译：N-酰基乙醇胺与胆固醇相互作用的差示扫描量热研究

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Earlier studies have suggested the formation of a 1 : 1 (mol/mol) complex between N-myristoylethanolamine (NMEA) and cholesterol in aqueous dispersion. In this study, this interaction has been investigated further by differential scanning calorimetry (DSC) on dry mixtures of NMEA, N-palmitoylethanolamine (NPEA) and N-stearoylethanolamine (NSEA) with cholesterol. The results obtained indicate that addition of cholesterol to NMEA leads to a new phase transition at 86.5 degrees C, besides the solid-liquid phase transition of NMEA at 95 degrees C. The intensity of the peak corresponding to the new transition increases with cholesterol content up to 50 mol%, but decreases thereafter, whereas the intensity of the peak corresponding to the melting of NMEA decreases with increasing cholesterol content, with concomitant and gradual shift to lower temperatures and vanishes at 50 mol% cholesterol. These results are consistent with the formation of a 1: 1 molar complex between NMEA and cholesterol proposed earlier and indicate that these two am-phiphiles are associated in the solid state as well. DSC studies on hydrated mixtures of NPEA and NSEA with cholesterol yielded results that parallel those obtained with the NMEA/cholesterol system, indicating that these two long-chain NAEs also form 1 : 1 (mol/mol) complexes with cholesterol.
机译：较早的研究表明，水分散液中N-肉豆蔻基乙醇胺（NMEA）与胆固醇之间会形成1：1（mol / mol）的复合物。在这项研究中，已通过差示扫描量热法（DSC）对NMEA，N-棕榈酰乙醇胺（NPEA）和N-硬脂酰乙醇胺（NSEA）与胆固醇的干燥混合物进行了进一步研究。获得的结果表明，向NMEA中添加胆固醇会导致在86.5摄氏度下出现新的相变，除了在95摄氏度时NMEA发生固-液相转变之外。与新转变相对应的峰强度随着胆固醇含量的增加而增加。降低至50mol％，但是此后降低，而与NMEA熔融相对应的峰的强度随着胆固醇含量的增加而降低，伴随并逐渐转移至较低的温度，并在50mol％的胆固醇下消失。这些结果与较早提出的NMEA与胆固醇之间1：1摩尔配合物的形成相吻合，表明这两种两亲物也以固态缔合。 DSC对NPEA和NSEA与胆固醇的水合混合物的研究得出的结果与NMEA /胆固醇系统获得的结果相似，表明这两个长链NAE也与胆固醇形成1：1（mol / mol）的复合物。

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