Role of levosimendan in sepsis and septic shock.

Pinto BB; Rehberg S; Ertmer C; Westphal M

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Role of levosimendan in sepsis and septic shock.

机译：左西孟旦在败血症和败血性休克中的作用。

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PURPOSE OF REVIEW: To present the pharmacologic and biologic profile of levosimendan and discuss potential indications in the treatment of sepsis and septic shock, with a special focus on myocardial and pulmonary dysfunction. RECENT FINDINGS: In animal models of endotoxic shock, levosimendan improved both left ventricular systolic and diastolic dysfunction, as well as ventriculovascular coupling. In addition, positive effects have been reported on right ventricular performance and pulmonary circulation. Two randomized, controlled trials in patients with septic shock revealed levosimendan provided consistent beneficial effects on cardiopulmonary performance, global oxygen transport, splanchnic perfusion and renal function. These effects have been reported as superior to placebo and the classic inotropic agent dobutamine. Due to its vasodilatory effects, combination with vasoconstrictor agents may be crucial in the presence of arterial hypotension. SUMMARY: There is increasing evidence that levosimendan exerts beneficial effects in the treatment of sepsis-induced myocardial and pulmonary dysfunction. Future large-scale multicenter clinical trials are now needed to clarify whether levosimendan improves the overall outcome of patients with sepsis and septic shock.

机译：审查目的：介绍左西孟旦的药理和生物学特性，并讨论败血症和败血性休克治疗的潜在适应症，特别关注心肌和肺功能障碍。最新发现：在内毒素性休克的动物模型中，左西孟旦改善了左心室收缩和舒张功能障碍，以及心室血管耦合。此外，据报道对右心室功能和肺循环有积极作用。在败血性休克患者中进行的两项随机对照试验表明，左西孟旦对心肺功能，整体氧转运，内脏灌注和肾功能均具有持续的有益作用。据报道这些作用优于安慰剂和经典的正性肌力药多巴酚丁胺。由于其血管舒张作用，在存在动脉低血压的情况下，与血管收缩药合用可能至关重要。摘要：越来越多的证据表明左西孟旦在败血症引起的心肌和肺功能障碍的治疗中发挥有益作用。现在需要未来的大型多中心临床试验来阐明左西孟旦是否可以改善败血症和败血性休克患者的总体疗效。

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《Current opinion in anaesthesiology》 |2008年第2期|共10页
作者
Pinto BB; Rehberg S; Ertmer C; Westphal M;
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正文语种 eng
中图分类外科手术学;
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Animals; Calcium; Dose-Response Relationship; Drug; Drug Interactions; Endotoxemia; 动物; 钙; 剂量效应关系; 药物; 药物相互作用; 内毒素血症; 腙类; 钾通道; 哒嗪类;

机译：Animals;Calcium;Dose-Response Relationship;Drug;Drug Interactions;Endotoxemia;动物;钙;剂量效应关系;药物;药物相互作用;内毒素血症;腙类;钾通道;哒嗪类;

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专利

1. Role of levosimendan in sepsis and septic shock. [J] . Pinto BB, Rehberg S, Ertmer C, Current opinion in anaesthesiology . 2008,第2期

机译：左西孟旦在败血症和败血性休克中的作用。
2. Effects of combined levosimendan and vasopressin on pulmonary function in porcine septic shock. [J] . Muhuo Ji, Renqi Li, Guo-min Li, Inflammation . 2012,第3期

机译：左西孟旦联合加压素对猪败血症性休克肺功能的影响。
3. Combined arginine vasopressin and levosimendan: A promising therapy for septic shock. [J] . Yang JJ, Wang X, Ji MH, Critical care medicine . 2011,第4期

机译：精氨酸加压素和左西孟旦联合治疗：败血性休克的有前途的治疗方法。
4. Relation of heart rate variability to serum levels of C-reactive protein in patients with severe sepsis and septic shock [C] . Papaioannou V.P., Dragoumanis C.D., Pneumatikos I.P. Computers in Cardiology, 2009 . 2009

机译：严重败血症和败血性休克患者心率变异性与血清C反应蛋白水平的关系
5. Formulation and evaluation of catalase microspheres in septic shock. [D] . Siwale, Rodney Chisanga Ntasulwa Telefya. 2008

机译：败血性休克中过氧化氢酶微球的配制和评估。
6. Therapies for sepsis. Emerging therapies for sepsis and septic shock. [O] . E Abraham 1997

机译：败血症治疗。脓毒症和脓毒性休克的新兴疗法。
7. Early identification of SIRS/sepsis prevents the development of severe sepsis and septic shock. How can nurses identify SIRS/sepsis at an early stage? [O] . Wiseth Marte Elise 2014

机译：早期识别SIRS /败血症可预防严重的败血症和败血性休克的发展。护士如何在早期识别出SIRS /败血症？
8. Possible Role of Bacterial Adherence and Bacterial Adhesions in Sepsis and Septic Shock [R] . Williams, T., Gartner, S., Hoban, L., 1989

机译：脓毒症和感染性休克中细菌粘附和细菌粘附的可能作用

Role of levosimendan in sepsis and septic shock.

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