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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Electrochemiluminescent sensors as a screening strategy for psychoactive substances within biological matrices
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Electrochemiluminescent sensors as a screening strategy for psychoactive substances within biological matrices

机译：电化学发光传感器作为生物学矩阵内精神物质的筛选策略

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摘要

With the rapid growth and appearance of novel psychoactive substances (NPS) onto the global drug market, the need for alternative screening methodologies for implementation within clinical environments is substantial. The immunoassay methods currently in use are inadequate for this new drug trend with the potential for misdiagnosis and subsequent administration of incorrect patient treatment increased. This contribution illustrates a strong proof-of-concept for the use of electrochemiluminescence (ECL) as a screening methodology for NPS within biological fluids, using the hallucinogen scopolamine as a model compound. A low cost, easy-to-use and portable sensor has been developed and successfully employed for the detection of scopolamine at clinically relevant concentrations within a variety of biological matrices, including human pooled serum, urine, artificial saliva and sweat, without any prior sample preparation required. Moreover, assessment of the sensor's potential as a point-of-care wearable device was performed with sample collection from the surface of skin, demonstrating its capability for the qualitative identification of scopolamine despite collection of only minimal volumes off the skins surface. The developed sensor described herein exhibits a strong proof-of-concept for the employment of such ECL sensors as point-of-care devices, where the sensors ease of use and removal of time-consuming and complex sample preparation methods will ultimately increase its usability by physicians, widening the avenues where ECL sensors could be employed.
机译：随着国民经济的快速增长和新的精神活性物质（NPS）的外观在全球药品市场中，需要替代筛选方法用于临床环境中的执行是巨大的。该免疫测定法目前使用的不足与误诊和不正确的患者治疗的后续管理增加了潜在的这种新药的趋势。这方面的贡献说明了使用电化学发光（ECL）作为生物液体中核动力源筛选方法得到有力的证明了概念，用迷幻剂东莨菪碱作为模型化合物。甲成本低，易于使用的和便携式传感器已被开发并成功地用于检测东莨菪碱的临床相关浓度的多种生物基质的内，包括人合并的血清，尿液，人工唾液和汗液，没有任何事先样品准备必需的。此外，与样本收集从皮肤表面进行传感器的潜能作为一个点照护穿戴设备的评估，表明其能力为东莨菪碱的定性鉴别，尽管只有很少的卷离皮肤表面的集合。发达传感器本文描述表现出强的证明的概念对于采用这种ECL传感器作为定点护理装置，其中所述传感器易用性和除去费时和复杂的样品制备方法的将最终增加其使用性由医生，加宽其中ECL传感器可使用的途径。

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