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Metal ions and the extracellular matrix in tumor migration

机译:金属离子和肿瘤迁移中的细胞外基质

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abstract type="main" xml:id="febs14986-abs-0001" xml:lang="en"> p>In this review, we explore the roles of divalent metal ions in structure and function within the extracellular matrix (ECM), specifically, their interaction with glycosaminoglycans (GAGs) during tumor progression. Metals and GAGs have been individually associated with physiological and pathological processes, however, their combined activities in regulating cell behavior and ECM remodeling have not been fully explored to date. During tumor progression, divalent metals and GAGs participate in central processes, such as cell migration and angiogenesis, either by modulating cell surface molecules, as well as soluble signaling factors. In addition, studies on metals and polysaccharides interactions have been of great value, as they provide structural information that can be correlated with function. Finally, we believe that understanding how metals are regulated in physiological and pathological conditions is paramount for the development of new treatment strategies, as well as diagnostic and exploratory tools./p> /abstract>
机译:<抽象类型= “主要” 的xml:ID = “febs14986-ABS-0001” 的xml:郎= “EN”>< p>在本文中,我们探索细胞外内二价金属离子的结构和功能的作用基质(ECM),具体而言,它们与糖胺聚糖(GAG的)肿瘤进展过程中的相互作用。金属和糖胺聚糖具有生理和病理过程被个别对应,但是,在调节细胞的行为和ECM重塑它们的联合活动还没有得到充分的探讨至今。在肿瘤进展,二价金属和GAG的参与中央过程,如细胞迁移和血管生成,或者通过调节细胞表面分子,以及可溶性信号因子。此外,对金属和多糖相互作用的研究有很大的价值,因为它们提供可与功能相关联的结构信息。最后,我们认为,了解金属如何在生理和病理条件调控是最重要的新的治疗策略的发展,以及诊断和探索性的工具和LT; / P>< /抽象>

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