...
首页> 外文期刊>The FEBS journal >p53 tumor suppressor and iron homeostasis
【24h】

p53 tumor suppressor and iron homeostasis

机译:p53肿瘤抑制器和铁稳态

获取原文
获取原文并翻译 | 示例
           

摘要

Iron is an essential nutrient for all living organisms and plays a vital role in many fundamental biochemical processes, such as oxygen transport, energy metabolism, and DNA synthesis. Due to its capability to produce free radicals, iron has deleterious effects and thus, its level needs to be tightly controlled in the body. Deregulation of iron metabolism is known to cause diseases, including anemia by iron deficiency and hereditary hemochromatosis by iron overload. Interestingly, dysregulated iron metabolism occurs frequently in tumor cells and contributes to tumorigenesis. In this review, we will discuss the role of p53 tumor suppressor in iron homeostasis.
机译:铁是所有生物体的必需营养素,在许多基本生化过程中起着至关重要的作用,例如氧气运输,能量代谢和DNA合成。 由于其生产自由基,铁具有有害影响,因此,其水平需要在体内紧密控制。 众所周知铁代谢的放松管制会引起疾病,包括贫血通过铁过载通过铁缺乏和遗传性血管瘤。 有趣的是,在肿瘤细胞中经常发生失调的铁代谢并有助于肿瘤发生。 在本综述中,我们将讨论P53肿瘤抑制在铁稳态中的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号