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Pharmacological Management of Psychosis in Parkinson Disease: A Review

机译:帕金森病精神病的药理管理:综述。

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摘要

Psychosis in Parkinson Disease (PDP) is a common clinical problem and presents a pharmacological therapeutic conundrum. Many patients with PDP require anti-parkinsonian drugs for motor control, but the use of these medications has been associated with worsening of the psychotic symptoms. Differences from other psychotic disorders include the association with the use of anti-parkinsonian drugs, and the common presentation with visual hallucinations. Understanding of the pathophysiology of this phenomenon in PD has grown over the last few decades with the realization that the dopaminergic system is not the sole player. This has led to pharmacological research beyond antipsychotics. In this article we review the general management of PDP, the available evidence for the pharmacological management of PDP, and the medications profile and safety. Useful tables, practical recommendations and treatment algorithm are proposed.
机译:帕金森病(PDP)中的精神病是一个常见的临床问题,并带来了药理学治疗难题。许多PDP患者需要抗帕金森氏症药物来控制运动,但使用这些药物已使精神病症状恶化。与其他精神病性疾病的区别包括与使用抗帕金森氏症药物的关联以及视觉幻觉的常见表现。在过去的几十年中,随着对多巴胺能系统不是唯一的参与者的了解,人们对PD中这种现象的病理生理学的了解日益加深。这导致了抗精神病药以外的药理研究。在本文中,我们回顾了PDP的一般管理,PDP药理学管理的可用证据以及药物概况和安全性。提出了有用的表格,实用建议和处理算法。

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