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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents [Review]
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Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents [Review]

机译：海藻中类肝素活性硫酸化多糖作为潜在的抗凝血剂[综述]

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摘要

Anticoagulant properties of marine algae have been extensively studied for the last 60 years. Sulphated polysaccharides (SPS) of three major divisions of marine algae, viz, Rhodophyta, Phaeophyta and Chlorophyta are reported to have such properties. Some of the active components have been chemically well characterized. Sulphated galactans and fucoidan sulphates from red and brown algae, respectively, and different sugar sulphates like arabinan, rhamnan sulphates, etc. from green algae are the active molecular species identified. Activity is related to the molecular size, type of sugar and sulphate content of the active componnt. Sulphate position, type of linkage and molecular geometry are also known to have a role in activity. The proposed mechanisms of action are predominantly on HC-II mediated antithrombin activities, direct antithrombin action (thrombin-fibrinogen complex) and minor AT-III involvements. Little anti-factor Xa and fibrinolytic activities are also proposed. Therapeutic interest of algal SPS as anticoagulant has recently been in focus. In future, algal SPS can be developed as anticoagulant/antithrombotic agents or could be used as a model for the same. [References: 144]
机译：在过去的60年中，对海藻的抗凝特性进行了广泛的研究。据报道，海藻的三个主要部分的硫酸化多糖（SPS）具有这种特性，即红藻，红藻，藻类和绿藻。在化学上已经很好地表征了一些活性成分。来自红藻和褐藻的硫酸化半乳聚糖和岩藻依聚糖硫酸盐，以及来自绿藻的不同糖类硫酸盐，如阿拉伯聚糖，鼠李糖硫酸酯等，是确定的活性分子种类。活性与活性成分的分子大小，糖类型和硫酸盐含量有关。硫酸盐的位置，键的类型和分子的几何形状也已知与活性有关。拟议的作用机制主要是针对HC-II介导的抗凝血酶活性，直接的抗凝血酶作用（凝血酶-纤维蛋白原复合物）和少量的AT-III参与。还提出了很少的抗Xa因子和纤溶活性。藻类SPS作为抗凝剂的治疗兴趣近来已成为焦点。将来，藻类SPS可以开发为抗凝剂/抗血栓形成剂，或可以用作其模型。 [参考：144]

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