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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >The bountiful and baffling baculovirus: The story of polyhedrintranscription
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The bountiful and baffling baculovirus: The story of polyhedrintranscription

机译：丰富而令人困惑的杆状病毒：多面体转录的故事

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摘要

Baculoviruses are a unique group of eukaryotic viruses that parasitize insects. The prototype member of the family Baculoviridae is Autographa californica multiple nuclear polyhedrosis virus (AcMNPV). Global interest in baculovirus biology stems from two important uses of baculoviruses - as biopesticides and as a highly favoured eukaryotic expression system for the large-scale production of recombinant proteins in the laboratory. Of late, baculoviruses have invited renewed interest by virtue of their potential use as a delivery system in gene therapy. Although the baculovirus expression vector system (BEVS) is extensively used worldwide, the transcriptional regulation of the hyperactive promoters used to drive foreign gene expression still remains shrouded in mystery. It is clear, however, that this regulation involves an intricate interplay of both host and viral factors. This review provides an overview of what we do know about the mechanisms of transcription of baculoviral genes, with special emphasis on the polyhedrin promoter, the workhorse promoter of the BEVS, and the insect cell host factors involved in enhancing transcription from it.
机译：杆状病毒是寄生昆虫的独特的一组真核病毒。杆状病毒科的原型成员是加利福尼亚州的Autographa californica多核多角体病毒（AcMNPV）。对杆状病毒生物学的全球关注源于杆状病毒的两种重要用途-作为生物农药和作为实验室大规模生产重组蛋白的真核表达系统。最近，杆状病毒由于其在基因治疗中作为传递系统的潜在用途而引起了新的兴趣。尽管杆状病毒表达载体系统（BEVS）在世界范围内得到广泛使用，但用于驱动外源基因表达的高活性启动子的转录调控仍然笼罩在谜团中。但是，很明显，该法规涉及宿主和病毒因素的复杂相互作用。这篇综述概述了我们对杆状病毒基因转录机制的了解，特别着重于多角体蛋白启动子，BEVS的主力启动子，以及涉及增强其转录的昆虫细胞宿主因子。

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