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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Carcinogenicity of the fern Pteridium aquilinum collected from enzootic bovine haematuria-free hilly area in India
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Carcinogenicity of the fern Pteridium aquilinum collected from enzootic bovine haematuria-free hilly area in India

机译：从印度无牛血尿的丘陵地区采集的蕨类蕨类植物的致癌性

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摘要

Chronic exposure in low doses to bracken fern (Pteridium aquilinum, family Pteridiaceae) has been associated with urinary bladder tumours and intermittent haematuria in bovines of hilly areas. In spite of the widespread distribution of the fern in the Himalayas and southern hills of the country, the disease is restricted to well-defined pockets. The possible reason for absence of the disease in other hilly areas even in presence of P. aquilinum could be due to lack of carcinogenic potential in the plant growing in such areas. In the present study, the fern was collected from an area where cases of bovine urinary bladder cancer and associated haematuria (enzootic bovine haematuria) have not been recorded. In these areas animals are left for grazing during rainy season. This fern was fed to guinea pigs for 30 months at the rate of 30% (w/w). The fern caused toxic and neoplastic changes in urinary bladders of the exposed animals. The incidence of tumours was 18.6%. The fern was found positive for the carcinogen ptaquiloside (3.74 +/- 0.6 mg/kg). The low level of ptaquiloside as compared to the values reported from elsewhere (0 to 9,776 mg/ kg; mean 1,257 mg/kg) and grazing during the period when grasses are abundant are perhaps the reasons for absence of the disease in such areas.
机译：低剂量长期服用蕨菜蕨（蕨类植物，蕨类科）与膀胱肿瘤和丘陵地区牛的间歇性血尿有关。尽管蕨类在该国的喜马拉雅山和南部丘陵中分布广泛，但该病仅限于轮廓分明的口袋中。即使在有丘陵假单胞菌的情况下，在其他丘陵地区也没有该病的可能原因可能是由于这些地区生长的植物缺乏致癌潜力。在本研究中，蕨类植物是从尚未记录牛膀胱癌和相关性血尿（动物性牛血尿）病例的地区收集的。这些地区的动物在雨季被放牧。将该蕨类动物以30％（w / w）的比率喂食豚鼠30个月。蕨类植物在暴露的动物的膀胱中引起毒性和肿瘤性变化。肿瘤的发生率为18.6％。发现蕨类植物的致癌物普他洛糖苷呈阳性（3.74 +/- 0.6 mg / kg）。与其他地方报道的值相比，普他洛糖苷的含量较低（0至9,776 mg / kg;平均1,257 mg / kg），而在草丛丰富的时期放牧可能是这些地区没有该病的原因。

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