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首页> 外文期刊>The Journal of Chemical Physics >Integrated rate laws for processive and distributive enzymatic turnover
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Integrated rate laws for processive and distributive enzymatic turnover

机译:加工和分配酶促成交量的综合税率法

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摘要

Recently derived steady-state differential rate laws for the catalytic turnover of molecules containing two substrate sites are reformulated as integrated rate laws. The analysis applies to a broad class of Markovian dynamic models, motivated by the varied and often complex mechanisms associated with DNA modifying enzymes. Analysis of experimental data for the methylation kinetics of DNA by Dam ( DNA adenine methyltransferase) is drastically improved through the use of integrated rate laws. Data that are too noisy for fitting to differential predictions are reliably interpreted through the integrated rate laws. Published under license by AIP Publishing.
机译:最近衍生的稳态差速率法用于含有两个底物位点的分子的催化转送率为综合速率法则。 该分析适用于广泛的马尔科维亚动态模型,其具有与DNA改性酶相关的各种和通常复杂机制的激励。 通过使用综合速率法,大坝(DNA腺嘌呤甲基转移酶)对DNA的甲基化动力学的实验数据分析。 通过综合速率法则可靠地解释对差异预测过度噪音过噪声的数据。 通过AIP发布在许可证下发布。

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