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首页> 外文期刊>Current Science: A Fortnightly Journal of Research >Influence of buthionine sulfoximine-mediated glutathione depletion on clastogenic activity of bleomycin and gamma-rays
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Influence of buthionine sulfoximine-mediated glutathione depletion on clastogenic activity of bleomycin and gamma-rays

机译：丁硫氨酸亚砜亚胺介导的谷胱甘肽耗竭对博来霉素和伽马射线致胶凝活性的影响

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摘要

The extent of induction of chromosome aberrations (CAs) by bleomycin (BLM) and gamma-rays has been compared in buthionine sulfoximine (BSO)-mediated reduced glutathione GSH-depleted human peripheral blood lymphocytes. The rationale for BSO treatment is based on the premise that GSH serves as a major endogenous cellular defence against various xenobiotics and GSH depletion itself may lead to significant sensitizations, Radiation and BLM-induced CAs were scored from Ist cycle metaphases in samples with or without BSO. BSO-treated samples showed higher sensitivity to radiation than the BSO-untreated one, whereas reduction in clastogenic action of BLM was observed in the BSO-treated sample. The frequency of all types of radiation-induced CAs was increased except exchanges. The reduced effect of BLM in GSH-depleted cells could be explained on the basis of failure of reactivation of the oxidized BLM by endogenous GSH whereas increased effect of radiation in GSH-depleted cells could be due to more free-radical induced DNA lesions, less DNA-shielding effect and low efficient repair. [References: 47]
机译：博莱霉素（BLM）和γ射线对染色体畸变（CAs）的诱导程度已在丁硫氨酸亚砜肟（BSO）介导的减少的谷胱甘肽GSH耗尽的人外周血淋巴细胞中进行了比较。 BSO治疗的基本原理是基于这样的前提，即GSH可以作为主要的内源性细胞防御各种异源生物的防御物，并且GSH耗竭本身可能导致显着的致敏性。在有或没有BSO的样品中，从Ist周期中期对放射和BLM诱导的CA评分。经BSO处理的样品比未经BSO处理的样品显示出更高的辐射敏感性，而在经过BSO处理的样品中观察到BLM的杀胶作用降低。除交换外，所有类型的辐射诱导CA的频率均增加。内源性谷胱甘肽无法使氧化的BLM重新激活，而GSH耗尽的细胞中BLM的作用降低可以解释，而GSH耗尽的细胞中放射作用的增加可能是由于自由基诱导的DNA损伤更多，更少DNA屏蔽作用和低效修复。 [参考：47]

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