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Nutriproteomics - Linking Proteomics Variation with Personalized Nutrition

机译：Nutriproteomics-将蛋白质组学变异与个性化营养联系起来

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Nutrition research has traditionally focused on providing adequate amounts of nutrients to nourish populations and prevent nutrient deficiencies. Modern nutrition science explores health-related aspects of bioactive components in foodstuffs at a subgroup rather than population level. Today's nutrition research focuses on promoting health, preventing or delaying the onset of disease, optimizing performance and assessing risk in individuals or subpopulations. Personalized nutrition means adapting food to individual needs, depending on host biological variation as well as life stage, style and situation. Nutrigenomics and nutrigenetics comprise the science to understand human genomic/genetic variability in preferences, requirements, and responses to diet and may become the future tools for personalized nutrition, health maintenance and disease prevention. The novel field of nutriproteomics builds upon and complements the field of nutrigenom-icsutrigenetics. Nutriproteomics has great potential as a tool for personalized nutrition. Specifically, nutriproteomics delivers two essential outputs for molecular nutrition research and applications in personalized nutrition: (1) the characterization and quantification of food-derived bioactive peptides and proteins and (2) the elucidation of biomarkers for mecha-nism-of-action, efficacy and side effects of nutritional interventions. This article introduces the new field of nutriproteomics in the context of nutrition and health research and discusses protein- and peptide-derived bioactives and biomarkers, highlights human proteome variability and how best to translate this field into personalized nutrition. The paper concludes with a status quo and outlook on nutriproteomics studies and technologies.
机译：传统上，营养研究的重点是提供足够的营养以滋养人口并防止营养缺乏。现代营养科学探索了食品中与生物活性成分有关的健康问题，这些问题涉及亚组而不是人群。当今的营养研究重点在于促进健康，预防或延缓疾病发作，优化绩效以及评估个体或亚群的风险。个性化营养意味着根据宿主的生物学差异以及生活阶段，风格和情况来使食物适应个人需求。营养基因组学和营养遗传学是一门了解人类基因组/遗传变异对饮食的偏好，要求和反应的科学，并且可能成为未来个性化营养，健康维护和疾病预防的工具。营养基因组学的新领域建立在营养基因组学/营养遗传学领域之上，并对其进行了补充。 Nutriproteomics作为个性化营养的工具具有巨大潜力。具体而言，nutriproteomics提供了分子营养研究和个性化营养应用的两个基本输出：（1）食物衍生的生物活性肽和蛋白质的表征和定量;（2）阐明作用机理，功效的生物标志物营养干预的副作用。本文在营养和健康研究的背景下介绍了营养营养学的新领域，并讨论了蛋白质和肽衍生的生物活性物质和生物标记物，重点介绍了人类蛋白质组变异性以及如何最好地将这一领域转化为个性化营养。本文以营养营养学研究和技术的现状以及展望结束。

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