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首页> 外文期刊>The Journal of investigative dermatology. >Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study
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Exposure to Solar UVR Suppresses Cell-Mediated Immunization Responses in Humans: The Australian Ultraviolet Radiation and Immunity Study

机译：暴露于太阳能UVR抑制了人类中的细胞介导的免疫反应：澳大利亚紫外线辐射和免疫研究

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Animal and human studies show that exposure to solar-simulated UVR is immunomodulatory. Human studies that used natural sun exposure and controlled for confounding are rare. We immunized 217 healthy adults (age range = 18-40 years) with a T-celledependent antigen, keyhole limpet hemocyanin, and measured personal clothing-adjusted UVR exposure (for 5 days before and after immunization), lifetime cumulative UVR exposure, serum 25-hydroxyvitamin D concentration at immunization, and potential confounding factors. We tested cellular and humoral immune responses in relation to UVR exposure. The delayed-type hypersensitivity response to keyhole limpet hemocyanin recall challenge was lower in individuals with higher personal clothing-adjusted UVR exposure on the day before immunization (P = 0.015) and during intervals spanning the day before to 2-3 days after immunization. There was an incremental increase in T helper type 17 cells (as a proportion of CD4(+) T cells) from preimmunization to postimmunization in the high, compared with the low, personal clothing-adjusted UVR exposure group (0.31% vs. -0.39%, P = 0.004). Keyhole limpet hemocyanin-specific antibody titers were not associated with acute or cumulative UVR exposure or serum 25-hydroxyvitamin D levels. Higher UVR exposure at antigen sensitization was associated with a reduced delayed-type hypersensitivity response and altered T helper type 17 kinetics. This has implications for the effectiveness of vaccinations and susceptibility to infections that rely on cell-mediated immune responses.
机译：动物和人类研究表明，暴露于太阳模拟的UVR是免疫调节性的。使用天然阳光暴露并控制混淆的人类研究很少见。我们免疫217名健康成人（年龄范围= 18-40岁），具有T-Celledendentent抗原，匙孔颗粒血晶素，并测量的个人服装调整的UVR暴露（免疫前后5天），寿命累积UVR暴露，血清25 - 羟基苯胺D浓度在免疫，以及潜在的混杂因子。我们测试了与UVR暴露有关的细胞和体液免疫应答。对匙孔颗粒血糖蛋白召回挑战的延迟型超敏反应在免疫前一天的个人服装调整的UVR暴露的个体中较低（P = 0.015），并且在免疫后2-3天的时间间隔期间。 T辅助型17型细胞的增量增加（作为CD4（+）T细胞的比例）从高处理到低温，与低，个人服装调整的UVR暴露组相比（0.31％Vs. -0.39 ％，p = 0.004）。匙孔颗粒血糖素特异性抗体滴度与急性或累积UVR暴露或血清25-羟基vitamind水平无关。抗原致敏的较高的UVR暴露与降低的延迟型超敏反应和改变的T辅助型17动力学相关。这对依赖细胞介导的免疫应答的疫苗疫苗和易感性的有效性具有影响。

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