...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in gastroenterology >Intestinal transplantation: an update.
【24h】

Intestinal transplantation: an update.

机译：肠移植：更新。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: As outcomes with intestinal transplantation continue to improve, its role in the management of intestinal failure patients becomes clearer. Some intestinal failure patients do well with long-term total parenteral nutrition (TPN), while others develop life-threatening complications and need to be evaluated for intestinal transplants (ITs). The purpose of this review is to update the current status of intestinal transplantation and its role in the management of intestinal failure patients. RECENT FINDINGS: Current outcomes indicate that intestinal transplants should be considered earlier in intestinal failure patients that develop liver injury, to prevent irreversible liver disease that would mandate a simultaneous liver transplant. Due to the small bowel (SB) graft's unique immunobiologic features, it is especially challenging to transplant successfully. Although new immunosuppressive strategies have been developed that appear to improve short-term results, their impact on long-term outcomes has yet to be shown. A better understanding of the interactions that occur between the SB's inherent immune system and its luminal flora may be required to devise strategies that will significantly curtail the SB graft's immunogenicity. SUMMARY: Intestinal transplantation remains a significant challenge. Ongoing efforts to better define the parameters that best predict total parenteral nutrition failure and the unique mechanisms that influence small bowel allograft outcomes are necessary before a broader application of small bowel transplantation can be indicated.
机译：审查目的：随着肠移植结果的不断改善，其在肠衰竭患者管理中的作用越来越明确。一些肠衰竭患者长期的全肠外营养（TPN）效果很好，而其他一些则出现危及生命的并发症，需要进行肠移植（IT）评估。本文的目的是更新肠移植的现状及其在肠衰竭患者管理中的作用。最新发现：目前的结果表明，对于发生肝损伤的肠衰竭患者，应及早考虑肠移植，以预防不可逆转的肝病，这种疾病要求同时进行肝移植。由于小肠（SB）移植物具有独特的免疫生物学特性，因此成功移植尤其具有挑战性。尽管已经开发出了新的免疫抑制策略，似乎可以改善短期结果，但它们对长期结果的影响尚未显示。可能需要更好地了解SB固有免疫系统与其腔内菌群之间发生的相互作用，以制定出显着降低SB移植物免疫原性的策略。总结：肠移植仍然是一项重大挑战。在表明广泛应用小肠移植之前，需要不断努力以更好地定义最能预测总肠胃外营养衰竭的参数以及影响小肠同种异体移植结果的独特机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号