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首页> 外文期刊>Current opinion in gastroenterology >Portal hypertension.
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Portal hypertension.

机译：门脉高压症。

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摘要

PURPOSE OF REVIEW: Significant advances in the pathophysiology, diagnosis and management of the complications of portal hypertension that have occurred in the last year are reported. RECENT FINDINGS: The specific areas reviewed are those that refer to experimental studies aimed at modifying the factors that lead to portal hypertension (increased intrahepatic vascular resistance and splanchnic vasodilatation) and recent advances in the diagnosis and management of the complications of portal hypertension. The specific complications reviewed in this paper are varices and variceal bleeding (primary prophylaxis, treatment of the acute episode and secondary prophylaxis), ascites and hepatorenal syndrome, spontaneous bacterial peritonitis and hepatic encephalopathy, as well as recent studies of predictors of death in cirrhosis. SUMMARY: Important studies, mostly prospective, regarding the management of the complications of portal hypertension are reviewed, including a trial of beta-blockers in the prevention of varices, a randomized trial of endoscopic variceal ligation plus nadolol in preventing recurrent variceal bleeding and several meta-analyses on trials comparing large-volume paracentesis with transjugular intrahepatic portosystemic shunt in the management of refractory ascites.
机译：审查目的：据报道，去年发生的门脉高压并发症的病理生理学，诊断和管理取得了重大进展。最近的发现：所审查的特定领域是针对那些旨在改变导致门脉高压的因素（肝内血管阻力和内脏血管扩张增加）以及门脉高压并发症的诊断和管理的最新进展的实验研究。本文所综述的具体并发症包括静脉曲张和静脉曲张破裂出血（主要预防，急性发作和继发性预防的治疗），腹水和肝肾综合征，自发性细菌性腹膜炎和肝性脑病，以及对肝硬化死亡的预测因素的最新研究。摘要：综述了有关门静脉高压症并发症处理的重要研究，其中大部分是前瞻性研究，包括β-受体阻滞剂预防静脉曲张的试验，内镜下静脉曲张结扎加纳多洛尔预防静脉曲张破裂性出血的随机试验以及一些meta -比较大剂量穿刺与经颈静脉肝内门体分流术治疗难治性腹水的试验分析。

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