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首页> 外文期刊>Current opinion in gastroenterology >Novel developments in non-erosive and erosive gastroesophageal reflux disease.
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Novel developments in non-erosive and erosive gastroesophageal reflux disease.

机译：非侵蚀性和侵蚀性胃食管反流病的新发展。

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PURPOSE OF REVIEW: Despite being clinically important and highly prevalent, several aspects of gastroesophageal reflux disease are incompletely understood. Research activity remains high, however, and we shall review some highlights from last year's publications. RECENT FINDINGS: Community based epidemiological studies have elucidated the risk factors for gastroesophageal reflux disease and demonstrated a significant risk for developing complications over time. New histological parameters such as distended intercellular spaces in the epithelium will detect minor signs of reflux damage. The esophageal endoscopic capsule has been studied as a way of screening for esophageal disease. Wireless pH-metry and impedance-pH-metry have increased our insight into the pathophysiology and improved the diagnostic work-up in atypical and therapy resistant cases. At the molecular level, the role of cytokines has been elucidated and there is increased support for the nitrosative stress theory for epithelial damage at the cardia. Endoscopic therapies have shown disappointing long-term results or safety concerns, leading to withdrawal of several methods. SUMMARY: The last year has brought significant development in diagnostic modalities, and increased our insight in the molecular events involved in the pathogenesis of gastroesophageal reflux disease. Ultimately, this may and must lead to new therapeutic modalities which will supplement proton pump inhibitors in medical therapy for gastroesophageal reflux disease.
机译：审查的目的：尽管在临床上很重要并且非常普遍，但是对胃食管反流疾病的几个方面还没有完全了解。但是，研究活动仍然很高，我们将回顾去年出版物中的一些要点。最近的发现：基于社区的流行病学研究已经阐明了胃食管反流疾病的危险因素，并显示出随着时间的流逝发生并发症的重大风险。新的组织学参数，例如上皮细胞间隙的扩大，将检测出反流损害的轻微迹象。已经研究了食道内窥镜胶囊作为筛查食道疾病的方法。无线pH测量和阻抗pH测量增加了我们对病理生理学的了解，并改善了对非典型和治疗耐药病例的诊断工作。在分子水平上，已经阐明了细胞因子的作用，并且增加了亚硝化应激理论对ia门上皮损伤的支持。内窥镜治疗显示出令人失望的长期结果或安全问题，导致几种方法的退出。总结：去年在诊断方式上取得了重大进展，并增加了我们对胃食管反流病发病机理中涉及的分子事件的认识。最终，这可能并且必须导致新的治疗方式，该方法将在胃食管反流疾病的医学治疗中补充质子泵抑制剂。

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