Galangal Pungent Component, 1'-Acetoxychavicol Acetate, Activates TRPA1

Masataka Narukawa; Kanako Koizumi; Yusaku Iwasaki

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Galangal Pungent Component, 1'-Acetoxychavicol Acetate, Activates TRPA1

机译：高良姜辛辣成分1'-乙酰氧查韦尔乙酸酯，激活TRPA1

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We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.

机译：我们调查了瞬态受体电位阳离子通道（TRP）的亚家族V，成员1（TRPV1）和TRP的亚家族A，成员1（TRPA1）的激活作用是由1'-乙酰氧基甲氧乙酸乙酸酯（ACA），高良姜的主要刺激性成分。 ACA不会激活表达TRPV1的人类胚胎肾（HEK）细胞，但会强烈激活表达TRPA1的HEK细胞。 ACA比典型的TRPA1激动剂异硫氰酸烯丙酯更有效。

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《Bioscience, Biotechnology, and Biochemistry》 |2010年第8期|共3页
作者
Masataka Narukawa; Kanako Koizumi; Yusaku Iwasaki;
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正文语种 eng
中图分类生物科学;
关键词
1'-acetoxychavicol acetate (ACA); transient receptor potential cation channel; subfamily A; member 1 (TRPA1); transient receptor potential cation channel; subfamily V; member 1 (TRPV1); intracellular Ca~(2+) concentration;

机译：1'-乙酸乙酰氧乙酸唑酯（ACA）;瞬时受体电位阳离子通道;亚家族A;成员1（TRPA1）;瞬时受体电位阳离子通道;亚家族V;成员1（TRPV1）;细胞内Ca〜（2+）浓度;

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1. Galangal Pungent Component, 1'-Acetoxychavicol Acetate, Activates TRPA1 [J] . Masataka Narukawa, Kanako Koizumi, Yusaku Iwasaki Bioscience, Biotechnology, and Biochemistry . 2010,第8期

机译：高良姜辛辣成分1'-乙酰氧查韦尔乙酸酯，激活TRPA1
2. The pungency of garlic: Activation of TRPA1 and TRPV1 in response to allicin [J] . Macpherson LJ, Geierstanger BH, Viswanath V, Current Biology: CB . 2005,第10期

机译：大蒜的辛辣：响应大蒜素激活TRPA1和TRPV1
3. Pungent products from garlic activate the sensory ion channel TRPA1 [J] . Bautista DM, Movahed P, Hinman A, Proceedings of the National Academy of Sciences of the United States of America . 2005,第34期

机译：大蒜的刺激性产品激活感觉离子通道TRPA1
4. Food components activating TRPA1 [C] . TATSUO WATANABE, YUSAKU IWASAKI, KENJI KOBATA, Recent researches in modern medicine . 2011

机译：食品成分激活TRPA1
5. A Multi-species Model for Selective Pruritus via the Direct Activation of TRPA1 [D] . Esancy, Kali Paige. 2020

机译：通过TRPA1直接激活选择性瘙痒的多种模型
6. Pungent products from garlic activate the sensory ion channel TRPA1 [O] . Diana M. Bautista, Pouya Movahed, Andrew Hinman, 2005

机译：大蒜的刺激性产品激活感觉离子通道TRPA1
7. Galangal Pungent Component, 1′-Acetoxychavicol Acetate, Activates TRPA1 [O] . Masataka NARUKAWA, Kanako KOIZUMI, Yusaku IWASAKI, 2010

机译：高良刺激性组分，1'-乙酰氧基吡啶酚，乙酸酯激活TRPA1
8. Effect of Activation Policies on Accession and Continuation in the Army Reserve Components: The Annualized Reserve Component Activation Cost of Leaving Model [R] . Doyle, C. 2008

机译：激活政策对陆军后备役部队加入和延续的影响：离职模型的年化后备部件激活成本

Galangal Pungent Component, 1'-Acetoxychavicol Acetate, Activates TRPA1

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