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首页> 外文期刊>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience >Dopamine Enhances Item Novelty Detection via Hippocampal and Associative Recall via Left Lateral Prefrontal Cortex Mechanisms
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Dopamine Enhances Item Novelty Detection via Hippocampal and Associative Recall via Left Lateral Prefrontal Cortex Mechanisms

机译：多巴胺通过海马和关联召回通过左侧前额外皮层机构提高物品新奇检测

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摘要

The involvement of fronto-striatal circuits in item and associative memory retrieval as well as in the stabilization of memories by retrieval practice suggests that both retrieval and re-encoding of stored memories might rely on dopaminergic mechanisms in humans. We tested these hypotheses in a placebo-controlled pharmacological fMRI study using 2 mg of the D2 antagonist haloperidol administered acutely before a cued associative recall task of previously encoded picture-word pairs in 53 healthy humans of both sexes. The cued associative recall was moreover repeated 3 d later outside the scanner without pharmacological intervention. Dopaminergic modulation significantly improved associative recall performance and recognition accuracy of verbal items. Moreover, we observed a significant dopamine effect on re-encoding in terms of increased specificity of associative memories from the first to the second cued associative recall. Better association memory under haloperidol was linked with higher activity in the left lateral prefrontal cortex and right parietal cortex, suggesting that dopamine facilitates associative retrieval through increased recruitment of frontoparietal monitoring processes. In contrast, improved recognition of verbal items under haloperidol was reflected by enhanced novelty detection in the hippocampus and increased activity in saliency networks. Together, these results show distinct but concomitant positive effects of dopamine on associative recall and item recognition and suggest that the specificity of associative recall through re-encoding mechanisms is likewise augmented by dopamine.
机译：在物品和联合记忆检索中的前方纹状体电路以及通过检索实践稳定的涉及表明，存储的记忆的检索和重新编码既可能依赖于人类的多巴胺能机制。我们在安慰剂控制的药理学FMRI研究中测试了使用2mg的D2拮抗剂Haloperidol在先前编码的两种性别的53个健康人类的呼应召回任务中持续施用2mg D2拮抗剂卤代丙酮醇。此外，在没有药理学干预的情况下，呼叫联想召回以后重复3天。多巴胺能调制显着改善了联想召回性能和识别准确性的口头物品。此外，我们观察到从第一届缔约方协会召回到第二次提议缔结召回的联想记忆的特异性方面重新编码了重新编码的显着多巴胺效应。较好的结合记忆下的卤代酮醇与左侧前额外皮层和右侧皮质较高的活性有关，表明多巴胺通过增加前期监测过程的招募来促进联合检索。相比之下，通过增强海马的新颖性检测和显着性网络的活动增加，改善了卤代洛尼醇下的口头物品的识别。这些结果在一起表明，多巴胺对联合召回和项目识别的鲜明而伴随着积极的影响，并表明通过重新编码机制的联合召回的特异性同样由多巴胺增强。

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