...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in hematology >Progress in the treatment of adults with acute lymphoblastic leukemia.
【24h】

Progress in the treatment of adults with acute lymphoblastic leukemia.

机译：成人急性淋巴细胞白血病的治疗进展。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: Despite improvements in the achievement of complete remission and progress in the supportive care of adults with acute lymphoblastic leukemia during the last decade, the majority of patients have eventually relapsed with overall survival in adult acute lymphoblastic leukemia of only 30-40%. However, the recent approach of adapting therapy according to biologic features appears to be resulting in significant progress for specific subsets of adults with acute lymphoblastic leukemia. RECENT FINDINGS: The present review highlights some of these new risk-adapted approaches focusing on recent advances in treatment of Philadelphia chromosome positive acute lymphoblastic leukemia and mature B-cell acute lymphoblastic leukemia using biologically targeted therapies, and new approaches to treatment of acute lymphoblastic leukemia in older adolescents and young adults, adopting therapeutic strategies employed in the successful treatment of children with acute lymphoblastic leukemia. A recent study that examines the role of allogeneic stem cell transplant for adults with acute lymphoblastic leukemia in first remission will also be reviewed. SUMMARY: The subset-specific approach to therapy of adult acute lymphoblastic leukemia is beginning to result in promising improvements in survival. Future improvements in survival of adults with acute lymphoblastic leukemia will depend on participation in large cooperative group trials using biologically defined protocols for this relatively rare and heterogeneous group of diseases.
机译：审查目的：尽管在过去十年中，成人急性淋巴细胞白血病的完全缓解和支持治疗取得了进步，但大多数患者最终仍以成人急性淋巴细胞白血病的总体存活率复发，仅为30-40％ 。但是，根据生物学特征调整治疗方法的最新方法似乎导致了急性淋巴细胞白血病的特定亚群的成年人取得重大进展。最近的发现：本综述重点介绍了一些新的适应风险的方法，重点是利用生物学靶向疗法治疗费城染色体阳性的急性淋巴细胞白血病和成熟的B细胞急性淋巴细胞白血病的最新进展，以及治疗急性淋巴细胞白血病的新方法在年长的青少年和年轻人中，采用成功治疗急性淋巴细胞白血病儿童的治疗策略。还将审查一项最近的研究，该研究研究了异基因干细胞移植对成人急性淋巴细胞白血病首次缓解的作用。摘要：治疗成人急性淋巴细胞白血病的亚组特异性方法开始导致生存率的改善。成年人急性淋巴细胞白血病的生存率未来的提高将取决于参与针对这种相对罕见且异质性疾病的生物学定义方案的大型合作组试验。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号