Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules.

Monu N; Trombetta ES

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Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules.

机译：MHC I类分子交叉呈递时，内吞途径与内质网之间的串扰。

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Cross-presentation of exogenous proteins on MHC class I complexes contributes to the priming CD8(+) T-cell responses. However, the mechanisms by which antigen-presenting cells transfer internalized proteins to the MHC class I loading pathway are not well understood. Endocytosed proteins often appear to require proteasomal processing and transport into the endoplasmic reticulum, but the intracellular routes involved in cross-presentation remain unclear. Understanding the molecular and cellular basis of cross-presentation will illuminate novel aspects of cell physiology and might lead to improved vaccine design.

机译：MHC I类复合物上的外源蛋白质的交叉展示有助于引发CD8（+）T细胞反应。但是，尚不清楚抗原呈递细胞将内在化的蛋白质转移至MHC I类负荷途径的机制。内吞蛋白通常似乎需要蛋白酶体加工并转运到内质网，但涉及交叉呈递的细胞内途径仍不清楚。了解交叉展示的分子和细胞基础将阐明细胞生理学的新方面，并可能导致改进疫苗设计。

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《Current opinion in immunology》 |2007年第1期|共7页
作者
Monu N; Trombetta ES;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Myosin Heavy Chains; Proteins; Endoplasmic Reticulum; g lt; 3gt; novel; 肌球蛋白重链; 蛋白质类; 内质网;

机译：Myosin Heavy Chains;Proteins;Endoplasmic Reticulum;g 3;novel;肌球蛋白重链;蛋白质类;内质网;

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1. Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules. [J] . Monu N, Trombetta ES Current opinion in immunology . 2007,第1期

机译：MHC I类分子交叉呈递时，内吞途径与内质网之间的串扰。
2. Hepatitis C virus envelope glycoprotein E1 originates in the endoplasmic reticulum and requires cytoplasmic processing for presentation by class I MHC molecules. [J] . Selby M, Erickson A, Dong C, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第2期

机译：丙型肝炎病毒包膜糖蛋白E1起源于内质网，需要胞浆处理才能通过I类MHC分子呈递。
3. Exogenous CLIP localizes into endocytic compartment of cells upon internalization: implications for antigen presentation by MHC class II molecules. [J] . Mukherjee R, Chaturvedi P, Lee-Chan E, Molecular Immunology . 2008,第8期

机译：内在化后，外源CLIP定位于细胞的内吞区室：对II类MHC分子呈递抗原的影响。
4. From Endoplasmic Reticulum to Secretory Granules: Role of Zinc in the Secretory Pathway of Growth Hormone [C] . Vibor Petkovic, Maria Consolata Miletta, Primus-E. Mullis European Society of Pediatric Endocrinology Advanced Seminar in Developmental Endocrinology . 2012

机译：从内质网到分泌颗粒：锌在生长激素分泌途径中的作用
5. Antigen processing in the endoplasmic reticulum for MHC class I molecules. [D] . Hammer, Gianna Elena. 2006

机译：内质网中MHC I类分子的抗原加工。
6. ERManI (Endoplasmic Reticulum Class I α-Mannosidase) Is Required for HIV-1 Envelope Glycoprotein Degradation via Endoplasmic Reticulum-associated Protein Degradation Pathway [O] . Tao Zhou, Dylan A. Frabutt, Kelley W. Moremen, 2015

机译：通过内质网相关蛋白降解途径降解HIV-1包膜糖蛋白需要ERManI（内质网I类α-甘露糖苷酶）
7. Cross-presentation of phage particle antigen in MHC class II and endoplasmic reticulum marker-positive compartments [O] . Ying Wan, Yuzhang Wu, Jingran Zhou, 2005

机译：MHC II类噬菌体颗粒抗原的交叉呈递和内质网标记阳性隔室

Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules.

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