...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journal of physical chemistry, A. Molecules, spectroscopy, kinetics, environment, & general theory >Selective Bond Excision in Nitroimidazoles by Electron Transfer Experiments
【24h】

Selective Bond Excision in Nitroimidazoles by Electron Transfer Experiments

机译：电子转移实验中硝基咪唑的选择性粘合切除

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have performed comprehensive charge-transfer experiments yielding negative ion formation in collisions of fast neutral potassium atoms with nitroimidazole and methylated derivative molecules. The anionic pattern reveals that in the unimolecular decomposition of the precursor parent anion, single and multiple bond cleavages are attained. Selective excision of hydrogen atoms from the N1 position in 4-nitroimidazole (4NI) is completely blocked upon methylation in 1-methyl-4-nitroimidazole (1m4NI) and 1-methyl-5-nitroimidazole (1m5NI). Additionally, only 4NI and 2-nitroimidazole (2NI) are efficient in selectively producing neutral (OH)-O-center dot and NO center dot radicals in contrast to 1m4NI and 1m5NI. These findings present a novel experimental evidence of selective chemical bond breaking by just tuning the proper collision energy in atom-molecule collision experiments. The present work contributes to the current need of pinpointing a class of charge-transfer collisions that exhibit selective reactivity of the kind demonstrated here, extending to tailored chemical control for different applications such as tumor radiation therapy through nitroimidazole-based radiosensitization.
机译：我们已经进行了全面的电荷转移实验，含有硝基咪唑和甲基化衍生物分子的快速中性钾原子碰撞中的负离子形成。阴离子模式显示，在前体亲肠阴离子的单分子分解中，获得单一和多键切割。从4-硝基咪唑（4NI）中的N1位置选择性切除来自NIIMIDAZOLE（4NI）的N1位置，在1-甲基-4-硝基咪唑（1M4NI）和1-甲基-5-硝基咪唑（1M5NI）中甲基化完全阻断。另外，仅4NI和2-硝基咪唑（2NI）在选择性地产生中性（OH）-O-中心点并且没有中央点自由基，与1M4NI和1M5NI相反。这些发现提出了一种新颖的一种通过在原子分子碰撞实验中调整适当的碰撞能量的选择性化学粘合性的实验证据。目前的作品有助于考虑一类表现出本类所证明的类型的电荷转移碰撞的电荷转移碰撞，延伸以根据基于Nitroimidazole的肿瘤放射敏化的不同应用量身定制的化学对照。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号