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首页> 外文期刊>Current opinion in gastroenterology >Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease
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Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease

机译：益生菌治疗肠易激综合症和炎症性肠病

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There is direct evidence that the pathogenesis of inflammatory bowel disease (IBD) involves the gastrointestinal microbiota and some evidence that the microbiota might also play a similar role in irritable bowel syndrome (IBS). The aim of this article is to review the emerging evidence for the mechanisms and effectiveness of probiotics in the management of these disorders.The composition of the gastrointestinal microbiota is strongly influenced by factors including age, diet and disease. Probiotics may be effective through their impact on the host gastrointestinal microbiota and promotion of mucosal immunoregulation. Probiotics are considered to be well tolerated, although the quality of studies and health claims has been variable. There are many short-term studies demonstrating the effectiveness of probiotics in IBS, although recommendations should be made for specific strains and for specific symptoms. Within IBD, a number of trials have shown the benefits of a range of probiotics in pouchitis and in ulcerative colitis, although current evidence in Crohn's disease is less promising.Clearly, some probiotics have considerable potential in the management of IBS and IBD; however, the benefits are strain specific. High-quality trials of probiotics in gastrointestinal disorders as well as laboratory investigations of their mechanism of action are required in order to understand who responds and why.
机译：有直接的证据表明炎症性肠病（IBD）的发病机制涉及胃肠道微生物群，还有一些证据表明该微生物群在肠易激综合症（IBS）中也可能起类似的作用。本文的目的是回顾益生菌在控制这些疾病中的作用机理和有效性的新兴证据。胃肠道微生物群的组成受到年龄，饮食和疾病等因素的强烈影响。益生菌可能通过影响宿主胃肠道菌群和促进粘膜免疫调节而有效。尽管研究和健康要求的质量参差不齐，但益生菌仍被认为具有良好的耐受性。有许多短期研究证明了益生菌在IBS中的有效性，尽管应该针对特定菌株和特定症状提出建议。在IBD内，许多试验表明了一系列益生菌在眼袋炎和溃疡性结肠炎中的益处，尽管目前在克罗恩病中的证据还不太乐观。显然，某些益生菌在IBS和IBD的治疗中具有相当大的潜力。但是，好处是特定于应变的。为了了解谁会做出反应以及为什么做出反应，需要进行益生菌在胃肠道疾病中的高质量试验以及它们的作用机理的实验室研究。

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