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首页> 外文期刊>Current opinion in HIV and AIDS >Do people with HIV infection have a higher risk of fracture compared with those without HIV infection?
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Do people with HIV infection have a higher risk of fracture compared with those without HIV infection?

机译：与没有感染艾滋病毒的人相比，感染艾滋病毒的人有更高的骨折风险吗？

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Purpose of reviewThis review details recent findings that inform the prevalence and incidence of fractures in people living with HIV (PLWH) and examines the effects of HIV infection and antiretroviral therapy (ART), as well as demographics and traditional risk factors on fractures. As antiretroviral guidelines have recently changed to recommend the introduction of ART at diagnosis of HIV infection, the long-term effects of ART on bone health and fracture risk need to be better understood.Recent findingsIt is apparent that both the effects of HIV infection alone and initiation of ART are associated with significant bone loss in individuals with HIV infection, resulting in osteopenia and osteoporosis. The clinical consequence of low bone mineral density is a greater risk of fragility fractures that are more common in older HIV patients, and those on ART. Frailty occurs at a prevalence of about 10% (about twice that of the general population), and the increased propensity of falls results in greater fracture prevalence, morbidity and mortality.SummaryThis review examines data from recent cohort studies and clinical trials to inform a better understanding of the complex relationship between the effects of HIV infection, ART and demographics on fractures in PLWH.
机译：审查的目的该审查详细介绍了最近的发现，这些发现可为HIV感染者（PLWH）骨折的发生率和发生率提供信息，并检查HIV感染和抗逆转录病毒疗法（ART）的影响以及人口统计学和传统的骨折危险因素。由于抗逆转录病毒指南最近已发生变化，建议在诊断HIV感染时引入抗逆转录病毒疗法，因此需要更好地了解抗逆转录病毒疗法对骨骼健康和骨折风险的长期影响。 ART的启动与HIV感染者的大量骨质流失有关，导致骨质减少和骨质疏松。低骨矿物质密度的临床后果是较大的脆性骨折风险，而这种脆性骨折在老年HIV患者和ART患者中更为常见。虚弱发生率约为10％（约为普通人群的两倍），跌倒倾向的增加导致骨折的发生率，发病率和死亡率更高。了解艾滋病毒感染，抗逆转录病毒疗法和人口统计学对PLWH骨折的复杂关系。

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