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首页> 外文期刊>The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical >Probing the Viscosity Dependence of Rate: Internal Friction or the Lack of Friction?
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Probing the Viscosity Dependence of Rate: Internal Friction or the Lack of Friction?

机译：探测率的粘度依赖性：内部摩擦或缺乏摩擦？

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摘要

Deviation from the Kramers' inverse viscosity dependence of rate, k proportional to 1/eta, is often attributed to the presence of internal friction in proteins after Ansari et al. in 1992 showed that the folding rate could fit k proportional to 1/(eta+ sigma) where a is considered the internal friction. Several experimental and computational studies thereafter used fits to Ansari's equation or extrapolated the rate to eta = 0 to estimate the internal friction in proteins and attributed its origin to various internal interactions such as ruggedness, dihedral rotation, and salt bridges. Here, we show that the above method to calculate the internal friction is incorrect since the rate in a simple model system without any internal friction yields a nonzero sigma. Further investigation reveals that sigma correlates with the relative deviation from Kramers' rate at different viscosities, where the deviation itself is caused due to the absence of full solvent friction rather than the presence of internal friction.
机译：从克拉默斯逆粘度速率的依赖性偏差，K正比于1 / ETA，常被安萨里等人后归因于内摩擦的蛋白质的存在。于1992年表明，折叠率可能适合ķ正比于1 /（ETA +西格玛），其中一个被认为是内部的摩擦。几个实验和计算研究之后被用于拟合到安萨里方程或外推的速度成ETA = 0来估计蛋白质中的内摩擦和归因其原产地各种内部的相互作用，例如耐用性，二面角旋转和盐桥。在这里，我们表明，计算内部摩擦上述方法是不正确，因为没有任何内部的摩擦在一个简单的模型系统中的速率产生非零西格马。进一步调查揭示了与来自克拉默斯在不同的粘度率，其中，所述偏差本身由于没有充分溶剂的摩擦，而不是内部摩擦的存在而引起的相对偏差，σ相关因素。

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