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首页> 外文期刊>The journal of physical chemistry, C. Nanomaterials and interfaces >Computed Atomic Force Microscopy Images of Chromosomes by Calculating Forces with Oscillating Probes
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Computed Atomic Force Microscopy Images of Chromosomes by Calculating Forces with Oscillating Probes

机译：通过用振荡探头计算力来计算染色体的染色体的原子力显微镜图像

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摘要

Atomic force microscopy (AFM) is a promising tool to visualize biomolecules at the sub-nanometer scale. Experimentally obtained AFM images have been compared with the simulated ones; however, such conventional images of biomolecules were usually computed by calculating equidistance surface from given atomic positions, not by calculating force. Here, we use a polymer model of a chromosome, as a representative biomolecule, and the AFM probe, and computed isoforce surfaces upon the fiber. The oscillation of probes utilized in the dynamic mode of AFM measurements was also implemented in the simulation. The computed isoforce images were clearer than the conventional equidistance ones, and a very similar images to isoforce ones were obtained when the diameter of the probe was reduced to approximately 30% in the equidistance images. Thus, the probe was found to approach very close to samples beyond the estimation of the equidistance surface, contributing clear AFM images. equidistance images.
机译：原子力显微镜（AFM）是一种有希望的工具，可在亚纳米尺度上可视化生物分子。 通过实验获得的AFM图像与模拟的图像进行了比较; 然而，通常通过从给定原子位置计算等距表面而不是通过计算力来计算这些生物分子的这种常规图像。 这里，我们使用染色体的聚合物模型，作为代表性生物分子和AFM探针，并且在纤维上计算的异构表面。 在模拟中也实施了AFM测量动态模式中使用的探针的振荡。 计算的异构图像比传统的等级图像更清晰，并且当探针的直径在等距图像中的直径降至约30％时，获得与异构的同学的非常相似的图像。 因此，发现探针非常接近超越等距表面的估计的样本，有助于透明AFM图像。 等距图像。

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