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首页> 外文期刊>Current opinion in lipidology >Free cholesterol in atherosclerotic plaques: where does it come from?
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Free cholesterol in atherosclerotic plaques: where does it come from?

机译：动脉粥样硬化斑块中的游离胆固醇：它来自何处？

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PURPOSE OF REVIEW: Free cholesterol in plaques is an emerging contributing factor to lesion instability and, until recently, apoptosis of lipid-laden macrophages was considered the major source of free cholesterol. The validity of this concept is beginning to be challenged since there is recent evidence of erythrocyte membrane-derived cholesterol in plaques. Therefore, intraplaque hemorrhage may not be a passive event, as once considered as studies continue to support the relationship of intraplaque hemorrhage and necrotic core expansion. RECENT FINDINGS: The association of intraplaque hemorrhage, accumulated free cholesterol, and necrotic core expansion is beginning to unfold and recent MRI studies suggest the value of intraplaque hemorrhage as a predictor of recurrent cerebrovascular events. The amount of erythrocyte membrane-derived cholesterol is also suggested to be a measure of lesion vulnerability in acute coronary syndromes. Recent inhibitors studies of vascular permeability factors further emphasize the importance of intraplaque hemorrhage in plaque progression. Finally, DNA microarray analysis is starting to reveal key molecules involved in the accumulation of free cholesterol that are selectively induced in high-risk plaques. SUMMARY: These recent findings emphasize the importance of intraplaque hemorrhage as a contributor of free cholesterol in plaques and point to its provocative role in lesion destabilization.
机译：审查目的：斑块中的游离胆固醇是病灶不稳定的新兴因素，直到最近，载脂类巨噬细胞的凋亡被认为是游离胆固醇的主要来源。由于最近有斑块中红细胞膜来源的胆固醇的证据，这一概念的有效性开始受到挑战。因此，斑块内出血可能不是被动事件，因为曾经被认为是研究继续支持斑块内出血与坏死核心扩展之间的关系。最近的发现：斑块内出血，游离胆固醇蓄积和坏死核心扩展之间的联系开始显现，最近的MRI研究表明斑块内出血的价值可作为复发性脑血管事件的预测指标。还建议将红细胞膜来源的胆固醇含量作为急性冠状动脉综合征中病变易损性的量度。最近对血管通透性因子的抑制剂研究进一步强调了斑块内出血在斑块进展中的重要性。最后，DNA微阵列分析开始揭示参与高胆固醇斑块中选择性诱导的游离胆固醇积累的关键分子。总结：这些最新发现强调了斑块内出血作为斑块中游离胆固醇贡献者的重要性，并指出了其在病灶不稳定中的促进作用。

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