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首页> 外文期刊>Current opinion in gastroenterology >The emergence of inflammatory bowel disease in the Asian Pacific region.
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The emergence of inflammatory bowel disease in the Asian Pacific region.

机译：亚太地区出现炎症性肠病。

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PURPOSE OF REVIEW: Inflammatory bowel disease has been traditionally considered rare in the Asian Pacific region, but recent evidence indicates that both Crohn disease and ulcerative colitis are becoming increasingly common among local populations. This review will validate this significant epidemiological and clinical observation using data published in the current Asian literature and information presented at the 2004 Asian Pacific Digestive Week in Beijing, China. RECENT FINDINGS: A progressive rise in the incidence and prevalence of inflammatory bowel disease is discernible is most Asian Pacific countries, more so for ulcerative colitis than Crohn disease. Some ethnic differences are notably evident, as Indians suffer more inflammatory bowel disease than Chinese or Malays. Age of onset and gender are similar to those of Western patients, as are the distribution and extent of disease which, however, tends to be clinically less severe than in European and North American patients. A family history is occasionally elicited, whereas smoking and appendectomy appear to have the same impact on inflammatory bowel disease as seen in the West. A remarkable difference is the absence of any association of Asian Crohn disease with NOD2/CARD15 mutations, as repeatedly observed in white and Jewish populations. Intestinal tuberculosis is still common in the Asian Pacific region, and poses major diagnostic and therapeutic hurdles, often delaying the diagnosis of true Crohn disease. SUMMARY: Investigation of inflammatory bowel disease in the Asian Pacific region offers the unprecedented opportunity to study the 'early stages' of the disease, and may provide new clues to its pathophysiology by identifying key environmental factors and distinct genetic make-ups.
机译：审查目的：炎症性肠病在亚洲太平洋地区历来被认为是罕见的，但是最近的证据表明，克罗恩病和溃疡性结肠炎在当地人群中正变得越来越普遍。这篇综述将利用当前亚洲文献中发表的数据和在中国北京举行的2004年亚太消化周上提供的信息，验证这一重要的流行病学和临床观察结果。最新发现：在大多数亚太国家中，炎症性肠病的发病率和患病率呈逐步上升的趋势，在溃疡性结肠炎中比在克罗恩病中更为明显。一些种族差异是显而易见的，因为印度人比中国人或马来人患有更多的炎症性肠病。发病年龄和性别与西方患者相似，疾病的分布和程度也与西方患者相似，但是在临床上其严重程度低于欧洲和北美患者。偶尔会引起家族病史，而吸烟和阑尾切除术对炎症性肠病的影响似乎与西方国家相同。一个显着的差异是，在白人和犹太人口中反复观察到，亚洲克罗恩病与NOD2 / CARD15突变之间没有任何联系。肠道结核在亚太地区仍然很普遍，并构成主要的诊断和治疗障碍，通常会延迟真正的克罗恩病的诊断。摘要：对亚太地区炎症性肠病的研究为研究该病的“早期阶段”提供了前所未有的机会，并可能通过确定关键的环境因素和独特的遗传组成为其病理生理提供新的线索。

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