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首页> 外文期刊>Current opinion in lipidology >The cellular biology of scavenger receptor class B type I.
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The cellular biology of scavenger receptor class B type I.

机译：I型清除剂受体的细胞生物学。

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摘要

The HDL receptor scavenger receptor class B type I plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. However, the mechanism by which scavenger receptor class B type I mediates selective cholesterol uptake is unclear. In hepatocytes scavenger receptor class B type I mediates the transcytosis of cholesterol into bile, appears to be expressed on both basolateral and apical membranes, and directly interacts with a PDZ domain containing protein that may modulate the activity of scavenger receptor class B type I. This suggests the involvement of scavenger receptor class B type I in higher order complexes in polarized cells. Scavenger receptor class B type I expression has been shown to alter plasma membrane cholesterol distribution and induce the formation of novel membrane structures, suggesting multiple roles for scavenger receptor class B type I in the cell. A close examination of scavenger receptor class B type I function in polarized cells may yield new insights into the mechanism of scavenger receptor class B type I-mediated HDL selective uptake and the effects of scavenger receptor class B type I on cellular cholesterol homeostasis.
机译：I类HDL受体清除剂受体在调节HDL衍生的胆固醇和胆固醇酯在肝脏和类固醇生成组织中的摄取中起着重要作用。但是，尚不清楚I类清除剂受体B介导选择性胆固醇摄取的机制。在肝细胞中，B类清道夫受体介导胆固醇的转胞作用进入胆汁，似乎在基底外侧膜和根尖膜上均表达，并且直接与可能调节I类清道夫受体活性的蛋白质的PDZ域相互作用。提示清道夫受体B类I型参与极化细胞的高级复合物。研究表明，清道夫受体B类I型表达可改变血浆膜胆固醇的分布并诱导新型膜结构的形成，提示清道夫受体B类I型在细胞中具有多种作用。仔细检查极化细胞中I类清道夫受体的功能可能会产生新的见解，以了解I类清道夫受体介导的HDL选择性摄取的机理以及I类清道夫受体对细胞胆固醇稳态的影响。

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