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首页> 外文期刊>Current opinion in lipidology >Synthetic and modified glycerides: effects on plasma lipids.
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Synthetic and modified glycerides: effects on plasma lipids.

机译:合成和改性甘油酯:对血浆脂质的影响。

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摘要

It has been suggested that the molecular species or structure of the triglyceride, i.e. not only what fatty acids are present but also their relative order in the sn1, 2, or 3 position on the triglyceride, can influence the metabolism of the triglyceride and its fatty acids, including lipoprotein metabolism. One rationale for this possibility assumes that the fatty acid in the sn2 position can be absorbed intact, i.e. as the sn2 monoglyceride, whereas the sn1,3 fatty acids are absorbed as free fatty acids that metabolize independently. Some sn2 monoglyceride might ultimately serve as the backbone for gut or liver phospholipids, exerting downstream influence on lipid metabolism. Experiments that test this hypothesis directly by feeding triglycerides with modified structure during carefully controlled fat intake are few, particularly in humans, but their results tend to support the paradigm.
机译:已经提出,甘油三酸酯的分子种类或结构,即不仅存在什么脂肪酸,而且它们在甘油三酸酯上的sn1、2或3位置的相对顺序,都可以影响甘油三酸酯及其脂肪的代谢。酸,包括脂蛋白代谢。这种可能性的一个基本原理是,可以完整吸收sn2位置的脂肪酸,即作为sn2单酸甘油酯,而sn1,3脂肪酸则作为独立代谢的游离脂肪酸被吸收。某些sn2单酸甘油酯最终可能会充当肠道或肝脏磷脂的骨架,对脂质代谢产生下游影响。很少有实验通过在精心控制的脂肪摄入期间通过喂入结构经过修饰的甘油三酸酯来直接检验这一假设,特别是在人类中,但其结果倾向于支持这一范例。

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