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Hypnotic and sedative drugs - Anything new on the horizon?

机译：催眠和镇静药物-即将出现新变化吗？

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PURPOSE OF REVIEW: Many studies of new intravenous sedative drugs have been published last year, including several phase I trials. This review provides a brief summary of these studies, with recommendations for selected reading. RECENT FINDINGS: Remimazolam is a rapidly metabolized benzodiazepine. Early clinical trials confirm more rapid recovery compared with midazolam. Etomidate analogues can be designed with rapid metabolism and without adrenocortical suppression, but research is only at the preclinical stage. MR04A3 and AZD3043 are gamma-aminobutyric acid A agonists with phase I data, but the outlook for further development is uncertain. Pioneers of intravenous emulsions of volatile anesthetics continue their work. SUMMARY: Many of the new sedative drugs were designed to undergo rapid metabolism. Remimazolam has great potential to enter clinical practice because of its rapid offset of action.
机译：审查目的：去年发表了许多新的静脉镇静药物研究，包括一些I期试验。这篇综述提供了这些研究的简要总结，并提供了一些阅读建议。最新发现：雷米唑仑是一种快速代谢的苯二氮卓。早期的临床试验证实，与咪达唑仑相比，其恢复更快。依托咪酯类似物可以被设计为具有新陈代谢快速且没有肾上腺皮质抑制的功能，但研究仅在临床前阶段。 MR04A3和AZD3043是具有I期数据的γ-氨基丁酸A激动剂，但进一步发展的前景尚不确定。挥发性麻醉剂静脉内乳剂的先驱者继续他们的工作。摘要：许多新的镇静药被设计为可以快速代谢。雷米唑仑因其迅速的作用抵消而具有进入临床实践的巨大潜力。

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