Recognition for Discoveries in DNA Repair

Hannah L. Klein; Lorraine S. Symington

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Recognition for Discoveries in DNA Repair

机译：识别DNA修复中的发现

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Recombination between homologous chromosomes is essential for successful meiosis. It drives genetic diversity in germline cells and provides the necessary scaffolding for accurate, balanced segregation of the parental chromosomes into meiotic products. However, its importance in somatic cells has only recently been appreciated and understood. It turns out that many genes involved in the DNA damage response encode constituents of the homologous recombination pathway, and defects in these genes result in predisposition to cancer and altered genomes. Tumors can now be categorized as homologous-recombination-deficient with the use of specific biomarkers, information that is critical to determining therapeutic strategy and assessing response. Thus, homologous recombination is critical to human health in several contexts.

机译：同源染色体之间的重组对于成功的减数分裂是必不可少的。它推动种系细胞的遗传多样性，并为亲本染色体的准确，平衡的分离提供必要的脚手架，进入减数分裂产物。然而，它在狭小细胞中的重要性最近才得到欣赏和理解。事实证明，许多参与同源重组途径的DNA损伤响应编码成分的许多基因，以及这些基因的缺陷导致癌症和改变的基因组。现在可以将肿瘤分类为使用特定生物标志物的同源重组缺陷，对确定治疗策略和评估反应至关重要的信息。因此，同源重组在几种情况下对人体健康至关重要。

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《The New England journal of medicine》 |2019年第7期|共3页
作者
Hannah L. Klein; Lorraine S. Symington;
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New York University Medical Center Department of Biochemistry and Molecular Pharmacology New York;

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正文语种 eng
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1. Recognition for Discoveries in DNA Repair [J] . Hannah L. Klein, Lorraine S. Symington The New England journal of medicine . 2019,第7期

机译：识别DNA修复中的发现
2. Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. [J] . D Mu, M Tursun, D R Duckett, Molecular and Cellular Biology . 1997,第2期

机译：通过人类错配修复和切除修复系统识别和修复复合DNA损伤（碱基损伤和错配）。
3. Finding a needle in the haystack: Recognition of DNA damage by collaboration between DNA repair proteins able to perform DNA charge transport [J] . BroshR.M. Cell cycle . 2012,第6期

机译：在大海捞针上找到针头：通过能够执行DNA电荷转运的DNA修复蛋白之间的协作来识别DNA损伤
4. Co(phen)2dpq3+-sheared DNA interactions: Investigation into the basis for major groove recognition and repair [C] . Yan-Bo Wu, Zhen-Hai Xiong, Hui-Li Chen, 第三届国际分子模拟与信息技术应用学术会议 . 2007

机译：Co（phen）2dpq 3 +-剪切的DNA相互作用：调查主要凹槽识别和修复的基础。
5. Synthesis of fluorinated analogs of oxidative DNA lesions and their use to probe features of recognition and repair by base excision repair glycosylases. [D] . Cao, Sheng. 2010

机译：氧化性DNA损伤的氟化类似物的合成及其在探测碱基切除修复糖基化酶识别和修复特征中的用途。
6. Focus: 50 Years of DNA Repair: The Yale SymposiumReports: Early Days of DNA Repair: Discovery of Nucleotide Excision Repair andHomology-Dependent Recombinational Repair [O] . W. Dean Rupp 2013

机译：焦点：DNA修复50年：耶鲁研讨会报告：DNA修复的早期：发现核苷酸切除修复和依赖同源性的重组修复
7. Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. [O] . Mu, D, Tursun, M, Duckett, D R, 1997

机译：通过人类错配修复和切除修复系统识别和修复复合DNA损伤（碱基损伤和错配）。
8. Abstracts of the Conference on Mechanisms of DNA Repair and Mutagenesis on the 100. Anniversary of the Discovery of Polonium and Radium [R] . 1997

机译：关于发现pol和镭周年纪念的DNa修复和诱变机制会议摘要

Recognition for Discoveries in DNA Repair

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