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首页> 外文期刊>Current opinion in lipidology >Clinical management of HIV-associated lipodystrophy.
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Clinical management of HIV-associated lipodystrophy.

机译：HIV相关脂肪营养不良的临床管理。

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PURPOSE OF REVIEW: Lipodystrophy or fat re-distribution, and its associated metabolic abnormalities, are common in HIV patients. The pathogenesis is multifactorial. This article provides an update on the latest findings of the different clinical management strategies that have been utilized in patients with lipodystrophy. RECENT FINDINGS: Treatment strategies need to be different in those patients with lipoatrophy when compared with patients with central fat accumulation (lipohypertrophy). Most of the treatments studied have produced minimal or modest effects, which are not sustained when the therapy is discontinued. The treatment of associated metabolic abnormalities such as insulin resistance and hyperlipidemia should have similar goals to that in the non-HIV population, but is complicated by the fact that response may be worse and there is a need to consider drug-drug interactions with the antiretrovirals. SUMMARY: Multiple complex strategies will need to be utilized in these patients to treat the different features seen in lipodystrophy in order to reduce their long-term cardiovascular risk. Further research is also needed to evaluate combination therapies and to identify the underlying mechanisms in order to develop novel therapies for the future.
机译：审查目的：脂肪营养不良或脂肪再分布及其相关的代谢异常在HIV患者中很常见。发病机理是多因素的。本文提供了有关脂肪营养不良患者已使用的不同临床管理策略的最新发现的最新信息。最近的发现：脂肪萎缩的患者与中央脂肪堆积（脂肪过多的患者）相比，治疗策略需要有所不同。所研究的大多数治疗方法均产生了最小或中等的效果，当停止治疗时这种效果无法持续。诸如胰岛素抵抗和高血脂症等相关代谢异常的治疗应具有与非HIV人群相似的目标，但由于反应可能较差，并且需要考虑药物与抗逆转录病毒药物的相互作用而使治疗变得复杂。概述：这些患者将需要采用多种复杂的策略来治疗脂肪营养不良所见的不同特征，以降低他们的长期心血管风险。还需要进一步的研究来评估组合疗法并确定潜在的机制，以便为将来开发新颖的疗法。

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