New developments in selective cholesteryl ester uptake

MeyerJ.M.; GrafG.A.; VanDerWesthuyzenD.R.

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New developments in selective cholesteryl ester uptake

机译：选择性胆固醇酯摄取的新进展

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PURPOSE OF REVIEW: Selective lipid uptake (SLU) is known to be a major pathway of lipoprotein cholesterol metabolism in experimental animals and humans, but remains poorly understood. This review provides a brief overview of SLU mediated by the HDL receptor scavenger receptor B-type I (SR-BI), and highlights several surprising new findings related to the impact of SLU pathways in cholesterol homeostasis. RECENT FINDINGS: Under certain conditions, SR-BI-mediated SLU contributes to reverse cholesterol transport (RCT) independently of ABCG5/G8-mediated biliary cholesterol secretion, implying a novel trafficking mechanism. Hepatic SR-BI expression and RCT are decreased in diabetic mice. Farnesoid X receptor (FXR) and the microRNAs miR-185, miR-96 and miR-223 are emerging therapeutic targets for increasing SR-BI expression. SR-BI-independent selective cholesteryl ester uptake is a newly characterized pathway in macrophage foam cells. SUMMARY: New findings underscore the importance of SR-BI-mediated SLU in hepatic SLU and RCT, while indicating that further investigation is needed to define SLU pathways, including SR-BI-independent macrophage selective cholesteryl ester uptake. The intracellular trafficking of cholesterol in these pathways appears to be critical to their normal function and is a major subject of ongoing studies.

机译：审查目的：选择性脂质摄取（SLU）是已知的实验动物和人类脂蛋白胆固醇代谢的主要途径，但仍知之甚少。这篇综述提供了由HDL受体清除剂受体B型I（SR-BI）介导的SLU的简要概述，并着重介绍了一些与SLU途径对胆固醇稳态相关的令人惊讶的新发现。最新发现：在某些条件下，SR-BI介导的SLU独立于ABCG5 / G8介导的胆汁胆固醇分泌而有助于逆转胆固醇转运（RCT），这暗示着一种新的贩运机制。糖尿病小鼠肝SR-BI表达和RCT降低。法呢类X受体（FXR）和microRNA miR-185，miR-96和miR-223是增加SR-BI表达的新兴治疗靶标。不依赖SR-BI的选择性胆固醇酯摄取是巨噬细胞泡沫细胞中一个新近表征的途径。简介：新发现强调了SR-BI介导的SLU在肝SLU和RCT中的重要性，同时表明需要进一步研究以定义SLU途径，包括不依赖SR-BI的巨噬细胞选择性胆固醇酯摄取。这些途径中细胞内胆固醇的运输似乎对其正常功能至关重要，并且是正在进行的研究的主要课题。

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《Current opinion in lipidology》 |2013年第5期|共7页
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MeyerJ.M.; GrafG.A.; VanDerWesthuyzenD.R.;
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1. Selective uptake of high density lipoproteins cholesteryl ester in the dog,a species lacking in cholesteryl ester transfer protein activity An in vivo approach using stable isotopes [J] . Khadija Ouguerram, Michel Krempf, Thierry Magot, Comparative biochemistry and physiology, Part B. Biochemistry & molecular biology . 2004,第4期

机译：缺乏胆固醇酯转移蛋白活性的狗中高密度脂蛋白胆固醇酯的选择性摄取一种使用稳定同位素的体内方法
2. SELECTIVE UPTAKE OF CHOLESTERYL ESTERS OF LOW-DENSITY LIPOPROTEINS IS MEDIATED BY THE LIPOPROTEIN-BINDING SITE IN HEPG2 CELLS AND IS FOLLOWED BY THE HYDROLYSIS OF CHOLESTERYL ESTERS [J] . Brissette L, Charest MC, Falstrault L The Biochemical Journal . 1996,第Pta3期

机译：低密度脂蛋白的胆固醇的选择性摄取是由脂蛋白结合位点介导的，在HEPG2细胞中，其后是胆固醇酯的水解
3. Selective uptake of cholesteryl esters of low-density lipoproteins is mediated by the lipoprotein-binding site in HepG2 cells and is followed by the hydrolysis of cholesteryl esters [J] . Louise BRISSETTE, Louise FALSTRAULT, Marie-Claude CHAREST The biochemical journal . 1996,第3期

机译：低密度脂蛋白的胆固醇酯的选择性摄取是由HepG2细胞中的脂蛋白结合位点介导的，然后水解胆固醇酯
4. Selective removal of cholesteryl ester in atherosclerotic plaque by nanosecond pulsed laser at 5.75 μm for less-invasive laser angioplasty [C] . Katsunori Ishii, Hideki Tsukimoto, Hisanao Hazama, Photonic therapeutics and diagnostics V . 2009

机译：纳秒脉冲激光以5.75μm选择性去除动脉粥样硬化斑块中的胆固醇酯
5. Regulation of low density lipoprotein receptor-related protein gene expression, and, Cholesteryl ester transfer protein-mediated HDL selective uptake in the liver. [D] . Gauthier, Andre. 2006

机译：调节低密度脂蛋白受体相关蛋白基因的表达，以及胆固醇酯转移蛋白介导的HDL在肝脏中的选择性摄取。
6. Selective uptake of cholesteryl esters of low-density lipoproteins is mediated by the lipoprotein-binding site in HepG2 cells and is followed by the hydrolysis of cholesteryl esters. [O] . L Brissette, M C Charest, L Falstrault 1996

机译：低密度脂蛋白的胆固醇酯的选择性摄取是由HepG2细胞中的脂蛋白结合位点介导的然后是胆固醇酯的水解。
7. Cholesteryl Ester Transfer Protein Mediates Selective Uptake of High Density Lipoprotein Cholesteryl Esters by Human Adipose Tissue [O] . Fabienne Benoist, Paulina Lau, Michael McDonnell, 1997

机译：胆固醇酯转移蛋白介导人类脂肪组织的选择性摄取高密度脂蛋白胆汁淤积酯

New developments in selective cholesteryl ester uptake

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