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首页> 外文期刊>Current opinion in lipidology >Metabolic endotoxaemia: Is it more than just a gut feeling?
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Metabolic endotoxaemia: Is it more than just a gut feeling?

机译：代谢性内毒素血症：不仅仅是肠道感觉？

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PURPOSE OF REVIEW: This article reviews the evidence linking gut bacteria, endotoxin, and its circulating levels with inflammatory induced obesity and metabolic disease (metabolic endotoxaemia). RECENT FINDINGS: Gut flora analyses have allowed gut microbiota signatures (GMS) to be observed in animal studies of obesity/metabolic disease. In these studies, specific GMS result in a change in obesity and metabolic disease state whereas in humans, analysis remains unclear. Serum studies, examining metabolic endotoxaemia as a biomarker, appear to link long-term cardiovascular disease and type 2 diabetes mellitus (T2DM) through activation of inflammatory pathways. More recent studies note the importance of diet, which shows the dramatic rise in endotoxin following acute or long-term high-fat diet, with the effects exacerbated in T2DM. SUMMARY: Gut flora appears to act as an important determinant in the pathogenesis of inflammatory induced obesity/T2DM. Endotoxin may act as the systemic insult, impacted by a high-fat diet, which may regulate this effect, combined with an altered GMS. As such, clinical and dietary intervention to affect this process - on the gut flora, the 'leaky' mucosal membrane and endotoxin coupled lipid absorption or removal of circulating endotoxin - could reduce the progression of inflammatory induced metabolic disease. ? 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
机译：审查目的：本文综述了将肠道细菌，内毒素及其循环水平与炎症性肥胖和代谢性疾病（代谢性内毒素血症）联系起来的证据。最近的发现：肠道菌群分析已使肥胖/代谢性疾病的动物研究中可以观察到肠道菌群特征（GMS）。在这些研究中，特定的GMS导致肥胖和代谢疾病状态发生变化，而在人类中，分析尚不清楚。血清研究将代谢性内毒素血症作为一种生物标志物进行研究，似乎通过激活炎症途径将长期心血管疾病与2型糖尿病（T2DM）联系起来。最近的研究注意到饮食的重要性，它显示了急性或长期高脂饮食后内毒素的急剧增加，这种影响在T2DM中更为严重。摘要：肠道菌群似乎是炎症性肥胖/ T2DM发病机理中的重要决定因素。内毒素可能是全身性损伤，受到高脂饮食的影响，而高脂饮食可能会调节这种作用，并伴有GMS改变。因此，影响这一过程的临床和饮食干预-对肠道菌群，“渗出”的粘膜和内毒素耦合的脂质吸收或循环内毒素的去除-可以减少炎症性代谢疾病的进展。 ？ 2013威科集团健康|利平科特·威廉姆斯和威尔金斯。

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