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Interstitial fluid lipoproteins

机译：间质液脂蛋白

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Purpose of review: The interstitium represents the fluid, proteins, solutes, and extracellular matrix comprising the microenvironment of tissues. We here review attempts to characterize the levels and composition of lipoproteins in human interstitial fluid, and identify potentially important questions for future research. Recent findings: Despite the high relevance of understanding how lipoproteins enter and exit the interstitial compartment, and how they interact with extracellular and cellular molecules, scientific progress in this field has been rather slow. This is partly due to methodological difficulties, both regarding how to obtain representative samples and how to perform appropriate measurements to compare patient cohorts and to evaluate responses to treatment. Predominant techniques include peripheral lymph cannulation and suction blister creation, both of which have inherent advantages and disadvantages. Detailed studies comparing the effects of long-term incubation of serum and lymph lipoproteins are compatible with the view that HDL in interstitial fluid takes up free cholesterol from cells and transfers it into the circulation. Summary: Studies of the concentration, composition, functionality, and turnover of interstitial fluid lipoproteins will be of great future interest for understanding how tissue cholesterol metabolism is regulated, and how different diseases link to increased risk for development of atherosclerosis.
机译：审查目的：间质代表构成组织微环境的液体，蛋白质，溶质和细胞外基质。我们在这里回顾了表征人间质液中脂蛋白水平和组成的尝试，并确定了可能用于未来研究的重要问题。最近的发现：尽管了解脂蛋白如何进入和离开间质区以及它们如何与细胞外和细胞分子相互作用具有高度相关性，但该领域的科学进展相当缓慢。这部分是由于方法上的困难，无论是在如何获得代表性样本以及如何进行适当的测量以比较患者队列和评估对治疗的反应方面。主要技术包括外周淋巴管插入术和吸引水疱的形成，两者都有其固有的优缺点。详细研究比较了长期孵育血清和淋巴脂蛋白的效果，这种观点与组织液中的HDL吸收了细胞中的游离胆固醇并将其转移到循环中的观点是一致的。简介：研究间质液脂蛋白的浓度，组成，功能和周转将对理解组织胆固醇代谢如何被调节以及不同疾病如何与动脉粥样硬化发展的风险增加有关具有重大的未来意义。

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