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Effect of inflammation on HDL structure and function

机译：炎症对HDL结构和功能的影响

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Purpose of reviewStudies have shown that chronic inflammatory disorders, such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis are associated with an increased risk of atherosclerotic cardiovascular disease. The mechanism by which inflammation increases cardiovascular disease is likely multifactorial but changes in HDL structure and function that occur during inflammation could play a role.Recent findingsHDL levels decrease with inflammation and there are marked changes in HDL-associated proteins. Serum amyloid A markedly increases whereas apolipoprotein A-I, lecithin:cholesterol acyltransferase, cholesterol ester transfer protein, paraoxonase 1, and apolipoprotein M decrease. The exact mechanism by which inflammation decreases HDL levels is not defined but decreases in apolipoprotein A-I production, increases in serum amyloid A, increases in endothelial lipase and secretory phospholipase A2 activity, and decreases in lecithin:cholesterol acyltransferase activity could all contribute. The changes in HDL induced by inflammation reduce the ability of HDL to participate in reverse cholesterol transport and protect LDL from oxidation.SummaryDuring inflammation multiple changes in HDL structure occur leading to alterations in HDL function. In the short term, these changes may be beneficial resulting in an increase in cholesterol in peripheral cells to improve host defense and repair but over the long term these changes may increase the risk of atherosclerosis.
机译：审查目的研究表明，慢性炎症性疾病（如类风湿性关节炎，系统性红斑狼疮和牛皮癣）与动脉粥样硬化性心血管疾病的风险增加相关。炎症增加心血管疾病的机制可能是多因素的，但在炎症过程中发生的HDL结构和功能改变可能起一定作用。最新发现HDL水平随炎症而降低，并且HDL相关蛋白发生明显变化。血清淀粉样蛋白A明显增加，而载脂蛋白A-1，卵磷脂：胆固醇酰基转移酶，胆固醇酯转移蛋白，对氧磷酶1和载脂蛋白M减少。炎症降低HDL水平的确切机制尚未明确，但会降低载脂蛋白A-1的产生，血清淀粉样蛋白A的增加，内皮脂肪酶和分泌性磷脂酶A2活性的增加以及卵磷脂：胆固醇酰基转移酶活性的降低。炎症引起的HDL变化降低了HDL参与胆固醇逆向转运并保护LDL免受氧化的能力。概述在炎症过程中，HDL结构发生了多种变化，从而导致HDL功能的改变。在短期内，这些变化可能是有益的，从而导致外周细胞中的胆固醇升高，从而改善宿主防御和修复，但从长期来看，这些变化可能会增加动脉粥样硬化的风险。

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