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首页> 外文期刊>Current opinion in hematology >Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells
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Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells

机译：1-磷酸鞘氨醇在造血干细胞运输和动员中的作用

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Purpose of Review: The 'mobilization' of hematopoietic stem cells (HSCs) out of the bone marrow and into the peripheral blood is used clinically to obtain HSCs for transplantation. Although generally successful, mobilization protocols remain imperfect and the mechanisms involved are not fully understood. This review discusses the latest findings in respect to the mechanisms involved in the egress of HSCs from the bone marrow into the circulation and the potential for these recent developments to improve mobilization procedures. RECENT FINDINGS: It has recently become apparent that the bioactive lipid sphingosine 1-phosphate (S1P) plays an active role in attracting HSCs into the peripheral blood. S1P is the first factor identified that provides a chemoattractant gradient promoting the movement of HSCs into the peripheral blood. Drugs that mimic S1P are available with others in development, raising the possibility of increasing the strength of the egress signal and thereby improving the efficacy of mobilization procedures. SUMMARY: S1P is the first egress factor described for HSCs, but the details of the underlying biology are only just emerging. Although manipulating the S1P axis to enhance mobilization protocols is an exciting possibility, much needs to be learned before improvements in mobilization strategies can be realized.
机译：审查目的：临床将造血干细胞（HSC）从骨髓“动员”到外周血中，以获取用于移植的HSC。尽管总的来说是成功的，但是动员协议仍然不完善，并且所涉及的机制还没有被完全理解。这篇综述讨论了有关HSCs从骨髓进入循环系统的机制的最新发现，以及这些近期发展对改善动员程序的潜力。最近的发现：最近发现，具有生物活性的脂质鞘氨醇1-磷酸（S1P）在将HSC吸引到外周血中起着积极的作用。 S1P是确定提供促进HSCs向外周血移动的趋化性梯度的第一个因素。模仿S1P的药物可与其他药物一起开发，从而增加了增强出口信号强度的可能性，从而提高了动员程序的效率。简介：S1P是描述为HSC的第一个出口因子，但是基础生物学的细节才刚刚出现。尽管操纵S1P轴来增强动员协议是一种令人兴奋的可能性，但是在实现动员策略的改进之前，还需要学习很多知识。

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