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首页> 外文期刊>Current opinion in hematology >Pathogen inactivation: Coming of age
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Pathogen inactivation: Coming of age

机译：病原体灭活：成年

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PURPOSE OF REVIEW: In the past 20 years, several pathogen inactivation technologies have been developed to be applied to blood components. This review is intended to summarize the data currently available about the technologies and the clinical use of products inactivated by those techniques. RECENT FINDINGS: Technologies for inactivating pathogens in plasma and platelets are available, and are increasingly used in many countries. Cumulative experience over the last decade in routine use supports the concept of the safety and efficacy of the blood components treated with pathogen inactivation technologies. SUMMARY: In recent years, an increase in the use of pathogen inactivation technologies for plasma and platelets has been observed. Their routine use in addition to experience generated in controlled clinical trials confirms that the treated blood components meet the required efficacy and safety criteria. Differences in epidemiology between countries, infectious risk perception, concerns about potential adverse effects associated with its use, and economic considerations of national blood systems might explain the differences observed in its implementation.
机译：审查目的：在过去的20年中，已开发出几种病原体灭活技术以应用于血液成分。这篇综述旨在总结有关该技术和被这些技术灭活的产品的临床使用的当前可用数据。最近的发现：可以使血浆和血小板中的病原体失活的技术已经存在，并且在许多国家中越来越多地使用。过去十年在常规使用中的累积经验支持了用病原体灭活技术处理的血液成分的安全性和有效性的概念。概述：近年来，已经观察到病原体灭活技术在血浆和血小板中的使用增加。除了在受控临床试验中产生的经验外，它们的常规使用还证实了所治疗的血液成分符合所需的功效和安全性标准。各国之间流行病学的差异，传染风险的感知，对与使用病毒有关的潜在不良影响的担忧以及国家血液系统的经济考虑，可能解释了在实施过程中观察到的差异。

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