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首页> 外文期刊>Current opinion in HIV and AIDS >What types of cancers are associated with immune suppression in HIV? Lessons from solid organ transplant recipients.
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What types of cancers are associated with immune suppression in HIV? Lessons from solid organ transplant recipients.

机译：哪些类型的癌症与HIV的免疫抑制有关？实体器官移植接受者的经验教训。

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PURPOSE OF REVIEW: To examine recently published evidence of cancer risk after solid organ transplantation to gain insight into cancers that are associated with immune suppression in HIV. RECENT FINDINGS: Data from several population-based studies comparing cancer risk in recipients of solid organ transplants with that in the general population have demonstrated increased risk for a broad range of cancers, predominantly those with a known or suspected infectious cause. This increase in risk is independent of cohort aging and probably independent of established behavioral and other risk factors for cancer. Epidemiological risk factor data are limited but appear to indicate a relationship with severity and duration of immune suppression. A recent meta-analysis indicates a striking similarity in the pattern of cancer occurrence in transplant recipients and people with HIV/AIDS. SUMMARY: The similarity of the increased risk of cancer in these two immunosuppressed populations, who differ with respect to their underlying conditions and lifestyles, is compelling evidence that these cancers are associated with immune deficiency. The mechanisms are not fully understood but appear to be related to impaired immune surveillance. These data challenge the classification of only a narrow range of cancers as associated with immune suppression in people with HIV/AIDS.
机译：审查目的：检查实体器官移植后最近发表的癌症风险证据，以深入了解与HIV免疫抑制有关的癌症。最近的发现：来自几项基于人群的研究数据比较了实体器官移植接受者和普通人群接受癌症的风险，这些结果表明，广泛的癌症风险增加，主要是那些已知或怀疑感染原因的癌症。风险的增加与队列的老化无关，并且可能与癌症的行为和其他风险因素无关。流行病学危险因素数据有限，但似乎表明与免疫抑制的严重程度和持续时间有关。最近的一项荟萃​​分析表明，在移植接受者和艾滋病毒/艾滋病患者中，癌症的发生方式具有惊人的相似性。简介：在这两个免疫抑制人群中，其基本病情和生活方式不同，其患癌风险增加的相似性，是令人信服的证据，表明这些癌症与免疫缺陷有关。该机制尚未完全了解，但似乎与免疫监测受损有关。这些数据挑战了与艾滋病毒/艾滋病患者免疫抑制有关的仅少数癌症的分类。

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